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Retina fatty acid composition

Effect of Feeding an n-3 Deficient Diet Beginning on Day 2 of Life on Adult Rat Retina Fatty Acid Composition ... [Pg.135]

Makrides M, Neumann MA, Byard RW. Simmer K, Gibson RA. Fatty acid composition of brain, retina, and erythrocytes in breast- and formula-fed infants. Am J Clin Nutr 1994 60(2) 189-194. [Pg.112]

Connor WE, Neuringer M. The effects of n-3 fatty acid deficiency and repletion upon the fatty acid composition and function of the brain and retina. In Kamovsky ML, Leaf A, Bolis LC, eds. Biological Membranes Aberrations in Membrane Structure and Function. Alan R Liss, New York, 1988, pp. 275-294. [Pg.122]

Philbrick DJ, Mahadevappa VG, Ackman RG, Holub BJ. Ingestion of fish oil or a derived n-3 fatty acid concentrate containing eicosapentaenoic acid affects fatty acid compositions of individual phospholipids of rat brain, sciatic nerve, and retina. J Nutr 1987 17 1663-1670. [Pg.192]

Futterman S, Downer JL, Hendrickson A. Effect of essential fatty acid deficiency on the fatty acid composition, morphology, and electroretinographic response of the retina. Invest Ophthalmol Vis Sci 1971 10 151-156. [Pg.214]

Neuringer M. The relationship of fatty acid composition to function in the retina and visual system. In Dobbing J, ed. Lipids, Learning and the Brain Fats in Infant Formulas, Report of the 103rd Ross Conference on Paediatric Research. Ross Laboratories, Columbus, OH, 1993. [Pg.215]

Fatty acid compositional changes in the retina of the rodent eye can also impact the development of vision, which, in turn, will affect behavior of the animal. Recent biochemical and biophysical studies have demonstrated how the response of rhodopsin to different membrane lipids may significantly affect vision. DHA is primarily associated with membrane proteins of the 7-TM motif (i.e., seven transmembrane spanning regions). Such 7- fM proteins are also associated with a G-protein-coupled event (activation of a phosphodiesterase which cleaves GTP to GDP). Rhodopsin is a typical 7-TM G-protein-coupled... [Pg.371]

Makrides, M., Neumann, M.A., Byard, R.W., Simmer, K., and Gibson, R.A. (1994) Fatty Acid Composition of Brain, Retina, and Erythrocytes in Breast- and Formula-Fed Infants, Am. J. Clin. Nutr. 60,189-194. [Pg.140]

The fatty acid composition of toad brain and retina glycerolipids is comparatively presented in Fig. 1. The toad brain lipids, although being more unsaturated as expected for a poikilotherm, share the general features known to be present in mammalian brain high concentration of arachidonate in PI and PE, and of docosahexaenoate in PS,... [Pg.398]

Table 1. Fatty acid composition of cattle retina glycerolipids. Table 1. Fatty acid composition of cattle retina glycerolipids.
The fatty acids of ROS phospholipids contain large amounts of polyunsaturated fatty acids (Anderson and Maude, 1972). The most abundant is docosahexaenoic acid (22 6a)3), which accounts for almost 50% of the total fatty acids in PE and PS. Several years ago, we attempted to take advantage of the turnover of photoreceptor membranes to replace the long chain polyunsaturates with shorter chain fatty acids by depriving albino rats of essential fatty acids (Anderson and Maude, 1972). To our surprise, after 10 weeks of essential fatty acid deprivation, the composition of the ROS phospholipids remained remarkably similar to that of the animals fed ordinary laboratory chow, although serum fatty acid compositions clearly demonstrated that the animals were deficient in the precursors of long chain polyunsaturated fatty acids. Subsequent experiments demonstrated that the renewal of photoreceptor membranes (Landis et at. 1973) and the electrical response of the retina (Benolken et at.y 1973) had been altered by essential fatty acid deficiency. [Pg.549]

The major forms of vitamin A (apart from carotene) are the esters of retinol with long chain fatty acids. Compared with the normal pattern of fatty acids in tissue lipids, they are a relatively select group and much more saturated. Palmitic acid predominates, together with smaller quantities of stearic and oleic acids. When the esters reach the lumen of the small intestine, they are almost completely hydrolysed, absorbed into the intestinal cells and reesterified. They are transported as components of the chylomicrons to the liver where they are stored almost entirely as retinyl palmitate, regardless of the composition of the dietary esters. Modification of dietary retinyl esters to such a specific fatty acid composition requires, as in the case of the cholesterol esters, specific hydrolytic and synthetic enzymes. These occur mainly in the liver, intestine and the retina of the eye. [Pg.183]

Lipid Composition. After the behavior experiments, the rats were killed by decapitation. Tissue samples including brain and retina were removed and stored at -80°C. The total lipid extracts of tissues were prepared according to the method of Folch et al. (39). Butylated hydroxytoluene (300 qg/sample) was added in methanol to each sample to minimize lipid oxidation. The total lipid extracts were trans-methylated with 14% BFj/methanol at 100°C for 60 min by a modification (40) of the method of Morrison and Smith (41). Fatty acid methyl esters were then analyzed on a Hewlett-Packard 5890 gas chromatograph (Hewlett-Packard, Palo Alto, CA) equipped with a flame ionization detector and fused silica capillary column (DB-FFAP, 30 m X 0.25 mm x 0.25 m, J W, Folsom, CA) with carrier gas (hydrogen) at a linear velocity of 50 cm/s. Injector and detector temperature were set to 250°C and oven temperature program was as follows 130 to 175°C at4°C/min, 175 to 210°C at l°C/min, and then to 245 at 30°C/min, with a final... [Pg.133]

Large quantities of docosahexaenoate are present in all retina glycerolipids, due to the contribution of lipids from the outer segments of photoreceptors, which are known to be enriched in this fatty acid. However, the same holds for diacylglycerols and phosphatidic acid, which likely are not concentrated in these structures. The unusual composition of these intermediates suggests that an important proportion of toad retinal lipid metabolism may be involved in supporting photoreceptor lipid composition. The concentration of both DG and PA is 4-5 fold higher in the toad than in the cattle retina (Aveldaho Bazan, 1974 and unpublished). [Pg.399]


See other pages where Retina fatty acid composition is mentioned: [Pg.381]    [Pg.381]    [Pg.100]    [Pg.116]    [Pg.166]    [Pg.169]    [Pg.195]    [Pg.616]    [Pg.124]    [Pg.120]    [Pg.23]    [Pg.134]    [Pg.1190]    [Pg.23]    [Pg.100]    [Pg.170]    [Pg.256]    [Pg.180]    [Pg.401]    [Pg.329]   
See also in sourсe #XX -- [ Pg.397 , Pg.547 ]




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