Response design

The Canadian licensing philosophy requires that each accident, together with failure of each safety system in turn, be assessed (and specified dose limits met) as part of the design and licensing process. In response, designers have provided CANDUs with two independent dedicated shutdown systems, and the likelihood of anticipated transients without scram is negligible. 

Minimizing tlie losses caused by an emergency requires planned procedures, understood responsibility, designated audiority, accepted accountability, and trained, e. perienced people. With a fiilly implemented plan, diese goals can be acliieved... 

Beydoun, A., Sackellares, J.C., and Shu, V. (1997) Safety and efficacy of divalproex sodium monotherapy in partial epilepsy a doubleblind, concentration-response design clinical trial. Depakote Monotherapy for Partial Seizures Study Group. Neurology 48 182-188. 

Relationship between response, design matrix and coefficients... 

Once the information needs and system modifications have been identified, work should continue to fully design data tasks for the metrics system. Avoid designing data collection tasks that require a significant departure from the responsible individual s normal activities. Requiring an individual to redirect his or her attention to a seemingly unrelated task can cause an individual to overlook or defer a metrics task due to the demands of his or her primary responsibilities. Designing the data collection tasks as an easy extension of existing responsibilities will achieve better acceptance and more reliable performance. 

In a concentration-response design, subjects receive either a fixed dose (or dose range) of a medicine and their plasma concentrations are... 

Pharmacokinetics/Pharmacodynamics Driven Exposure-Response Designs... 

Validation project management Validation responsibilities Design and validability review... 

A three level four factor three response design of RSM was employed to optimize the carrot dehydration process. The four factors were drying temperature in HTST fluidized bed dryer, exposure time in HTST fluidized bed dryer, concentration of biopolymers and blanching time. The three responses were rehydration ratio, bulk density and carotenoid loss during the process. Second degree polynomial equations and Statistical Analysis System were used to fit the data for RSM. 

For dehydration of diced potatoes, a three level four factor four responses design was used. The four factors stayed the same as in the carrot study. The four responses were rehydration ratio, bulk density, non-enzymatic browning and water holding capacity. Optimal conditions were determined to be 1450C arid 10 min in HTST fluidized bed dryer with blanching time of 4.5 min and biopolymer... 

Atherosclerosis may be thought of as an unintended consequence of normal physiological responses designed to... 

The problems faced by the traumatized individual are listed in Table I.The metabolic response to injury can be thought of as a protective physiological response designed to keep the individual alive until healing processes repairthe damage that has been done. It is mediated by a complex series of neuroendocrine and cellular prexesses, all of which contribute to the overall goal—surx ival. 

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