Response Surface Methodology second-order designs

Response surface methodology (RSM) is a method of optimization using statistical techniques based upon the special factorial designs of Box and Behenkini and Box and Wilson.I It is a scientific approach to determining optimum conditions which combines special experimental designs with Taylor first and second order equations. The RSM process determines the surface of the Taylor expansion curve which describes the response (yield, impurity level, etc.) The Taylor equation, which is the heart of the RSM method, has the form ... 

Optimization. The influence of the reaction parameters on the yield of the reaction were studied using response surface methodology (RSM). A central composite design was used and both canonical analysis of the second-order equation and discussion of the isoresponse curves were used for the interpretation of the results. 

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