Research informatics

Computational Drug Design Groups Department of Research Informatics Biogen Idee 12 Cambridge Center Cambridge, MA 02142 USA... 

Computational Dmg Design Groups Department of Research Informatics... 

Overall, these computational toxicology models and many others developed at the US Food and Drug Administration, Center for Drug Evaluation and Research, Informatics and Computational Safety Analysis Staff (ICSAS) can predict with considerable precision the toxicological... 

There is a rich and expanding universe of available software and hardware tools to implement a research IT environment such as the one described here. If there is any critical take-away message, it would be to be willing to adopt and leverage the excellent existing capabilities within the research landscape. If one must build, build where you add the most value, and, in all other areas, walk in the excellent shoes of those who have explored this landscape before you. Well-researched and carefully selected service components will pay back in the future in the form of a flexible architecture that can be retooled and redeployed with maximal reuse to address the changing needs of research informatics. 

Main focus of most pharmaceutical research organizations is to generate or acquire novel compounds and to characterize these in terms of various properties. The generated compound profiles serve as a basis for the conception of a next round of— hopefully—improved molecules. This cycle continues until a clinical candidate has been identified or a project has to be terminated. Most organizations have established a research informatics infrastructure to support these processes. A number of commercial software products are available today in this application area. Depending on the available resources, typical infrastructures rely on one or a combination of multiple commercial platforms that have been customized and extended to fit the specific needs of each organization [1 ]. 

Our investigation, within Terrance s (2000) classification of action research, was collaborative action research. The LON project team existed from three groups of partners Seven teachers from primary schools, six of whom conducted interventions in their schools the adviser for chemistry from the National Board of Education for Slovenia and three chemical education researchers from the Department of Chemical Education and Informatics, University of Ljubljana. 

Immunoinformatics is a newly emergent subdiscipline within the informatic sciences that deals specifically with the unique problems of the immune system. Like bioinformatics, immunoinformatics complements, but never replaces, laboratory experimentation. It allows researchers to address, in a systematic manner, the most important questions in the still highly empirical world of immunology and vaccine discovery. 

Gustafson DH, Hawkins RP, Boberg EW, et al. CHESS 10 years of research and development in consnmer health informatics for broad populations, inclnding the underserved. Int J Med Inform 2002 65 169-77. 

The author is grateful to Mr. H. Horiuchi for the preparation of photoelectrochemical cells. Professor S. Yamada for discussion, and Professor Y. Tanimoto and Associate Professor Y. Fujiwara for using the superconducting magnets. The author also thanks The Center of Advanced Instrumental Analysis, Kyushu University, for H-NMR measurements. This study was financially supported by the Grant-in-Aids for Scientific Research Priority Areas (Area 767, No. 15085203) and (Area 432, No. 17034051), Scientific Research (C) (No. 17550131), and twenty first century COE Program Function Innovation of Molecular Informatics from M EXTof the Japan. 

In-Kwon Yeo received the PhD degree in Statistics from University of Wisconsin-Madison in 1997. He joined the Department of Control and Instrumentation Engineering, Kangwon National University as a visiting professor in 2000 and the Division of Mathematics and Statistical Informatics, Chonbuk National University as an assistant professor in Korea. He is currently an associate professor at the Department of Statistics, Sookmyung Women s University. His current research interests include data transformations, multivariate time series analysis and generalized additive models. 

Molecular Informatics Structure and Design Pfizer Global Research and Development Ramsgate Road Sandwich, Kent CT13 9NJ UK... 

Dovidenko, K. Potyrailo, R. A. Grande, J., Focused ion beam microscope as an analytical tool for nanoscale characterization of gradient formulated polymeric sensor materials, In Combinatorial Methods and Informatics in Materials Science. Materials Research Society Symposium Proceedings Fasolka, M. Wang, Q. Potyrailo, R. A. Chikyow, T. Schubert, U. 

Certainly biomolecular NMR is not the single method which is important for hit identification in pharmaceutical research. It is always a combination of techniques and a team effort that leads to a successful drug. This can involve biologists (basic understanding, assay development, bio-informatics), chemists (both bench chemists and modelers), screening specialists (HTS/natural products) and spectroscopists (X-ray, optical methods, surface plasmon resonance, NMR). 

Table 1 Commercially and Publicly Available Compound Databases and Molecular Informatics Resources (see Section 5) for Chemogenomics Research. The list is not exhaustive, but rather constitutes a representative compilation of selected examples in this field.

Chemogenomics Laboratory, Research Unit on Biomedical Informatics, Municipal Institute of Medical Research and University Pompeu Fabra, Dr. Aiguadev 88, 08003 Barcelona, Catalonia, Spain. Email jmestres imim.es. 

It is worth noting that (scientific) data has intrinsic value, even if the primary purpose for which it was created, has long been fulfilled. Innovative (re-)uses of publicly available data on the internet exemplify this nicely. Scientists usually tend to produce data in the context of a specialized research project and disseminate it through the means of scientific publication in a learned journal. Once research objectives have been met or a publication has been published, scientists often lose interest in their own data as it serves no primary purpose anymore. Because of this, significant amounts of valuable scientific data either never get published and thus never become part of the knowledge commons or are rendered inaccessible to machines and thus effectively destroyed for informatics purposes. 

Fig. 9 The semantic layer-cake. (Copyright 2008 World Wide Web Consortium, (Massachusetts Institute of Technology, European Research Consortium for Informatics and Mathematics, Keio University). All Rights Reserved. http //www.w3.org/Consortium/Legal/2002/copyright-documents-20021231. Reproduced with permission)...

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