Reproductive chemicals

Muscles (heart, etc.) Stomach/intestine Liver Kidney (bowel) Reproductive organs Glands Brain (Chapter 9) Sense organs Digestion, fluid circulation, motion, mechanical work Major zones of digestion Major zone of synthesis Major external rejection ion/water balance Reproduction Chemical controls Electrical control Environmental detectors... 

Human teratogens and chemicals that have an effect on human reproduction Chemicals that are irritants to the skin, eyes, and respiratory system (data from human exposure or animal tests)... 

Reproductive toxins" means chemicals which affect the reproductive chemicals which affect the reproductive capabilities including chromosomal damage (mutations) and effects on fetuses (teratogenesis). 

Bone, L.W. Reproductive Chemical Communication of Helminths. I. Platyhel-minths. Int. J. Invert. Reprod. 5, 261-268 (1982). 

Luisi P L 1996 Seif-reproduction of miceiies and vesicies modeis for the mechanisms of iife from the perspective of compartmented chemistry Advances in Chemical Physics voi XCii, ed i Prigogine and S A Rice (New York Wiiey) pp 425-38... 

F. M. Sullivan and co-workers. The Toxicology of Chemicals, Series Two Reproductive Toxicity, Vol. 1, Commission of the European Communities, Bmssels, Belgium, 1993. 

The LD q for sodium bromide taken orally by rats is 3.5 g/kg body weight, and the TD q orally in rats is 720 mg/kg (8). RTECS Hsts data on reproductive effects in male and female rats. Sodium bromide is Hsted in the TSCA Inventory, the Canadian Domestic Substances Hst (DSL), the European Inventory of Existing Commercial Chemical Substances (EINECS), the Japanese Existing and New Chemical Substances (ENCS), and the Korean Existing Chemicals Hst (ECL). It is not regulated by the U.S. Department of Transportation. 

S. M. Badow and P. M. Sullivan, Reproductive Hazards of Industrial Chemicals, Academic Press, London, 1982, pp. 126—135. 

Electroforrning is the production or reproduction of articles by electro deposition upon a mandrel or mold that is subsequendy separated from the deposit. The separated electro deposit becomes the manufactured article. Of all the metals, copper and nickel are most widely used in electroforming. Mandrels are of two types permanent or expendable. Permanent mandrels are treated in a variety of ways to passivate the surface so that the deposit has very Httie or no adhesion to the mandrel, and separation is easily accompHshed without damaging the mandrel. Expendable mandrels are used where the shape of the electroform would prohibit removal of the mandrel without damage. Low melting alloys, metals that can be chemically dissolved without attack on the electroform, plastics that can be dissolved in solvents, ate typical examples. 

A major difficulty which has been encountered with these definitions (identified as a particular problem by EDSTAC) is the definition of the term adverse . For a chemical to be judged an ED, it is important to show that the response seen has an adverse effect on the health or reproductive capacity of affected organisms or populations and is not just a change which falls within the normal range of physiological variation. 

The impact of chemical pollution on the reproductive success and population sizes of wildlife species is often difficult to assess. In many cases, environmental factors such as habitat restriction, stress due to human intrusion and changes in natural food supplies owing to hunting, fishing and restocking policies may have a significant, even predominant, effect on population size. This makes it difficult to determine to what extent, if any, environmental endocrine disrupters may be contributing to observed effects on reproduction or population size in wildlife species. 

Another section of the EPA, the Office of Prevention, Pesticides, and Toxic Substances (OPPT), has recently updated and harmonized its testing guidelines for evaluating the developmental and reproductive effects of pesticides and industrial chemicals to include an assessment of endocrine disrupting properties. These guidelines will be used in future testing of pesticides under both the Toxic Substances Control Act (TSCA) and the Federal Insecticide, Fungicide and Rodenticide Act (FIFRA). 

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