Repackaging

Estimated production capacity for the Japanese producers is 77,000 t/yr for the American producers, about 70,000 t/yr and for the European producers about 50,000 t/yr (104). The Hst prices for the monomer have increased dramatically over the past 15 years, according to the ChemicalM.arketing Reporter (105). In 1975 the price for 50% solution was 0.903/kg, compared to 1.68/kg in December 1990 (100% basis, FOB plant). The sohd crystalline monomer always demands a premium price because of the added cost of production, and sold in December 1990 for 2.27/kg compared to 1.09/kg in 1975. There are at least 35 supphers of acrylamide monomer most of them obviously are repackagers. 

Eresh fmit and vegetable packaging is often in bulk in a variety of traditional wooden boxes and crates, and cormgated fiberboard cases. At or near the retail level, bulk produce may be repackaged in oxygen-permeable flexible materials such as PVC, with or without a tray of foamed polystyrene. 

Distribution Channels. Most commodity chemicals ate primarily sold by the producer to a relatively small number of very large users. However, producers of commodity chemicals also utilize disttibutors to teach small volume users. Distributors buy in bulk and repackage or resell in smaller amounts to a broad spectmm of users. Distributors profit by the difference between their bulk cost and their LCL (less-than-cadoad lots) sales plus a commission from the producer, which may be as high as 15% of the bulk price but is mote often 5 to 10%. 

Methyl bromide is sold both as the essentially pure compound, 99.5% minimum, with not more than 0.010% water and 0.001% acidity as HBr, and with small amounts of chloropicrin [76-06-2], CCI2NO2. During 1992 methyl bromide in tank cars was priced at 1.70/kg. Methyl bromide is suppHed in 37,850- and 60,560-L tank cars and in 12,220-L ISO cylinders. Repackagers supply methyl bromide in 0.45 kg or 0.68 kg cans for such appHcations as fumigating tobacco seed beds. Alone or in formulations, it is classified as a poison, class B, and requires a poison label. 

Completely Denatured Alcohol. Completely denatured alcohol (CD A) escapes the involved financial and administrative controls required of the other classifications of industrial ethanol. No tax is appHed, no bond is required, no permit is needed to enable a customer to purchase CD A. Requirements for records by both producer and user are minimal. These simplified regulations are possible because CDA is denatured with substances that render it totally unfit for beverage purposes. It is also unsuitable where odor is objectionable. CDA and products made from it are, however, governed by special labeling requirements of the BATE. Repackaging of completely denatured alcohol is permitted as long as labeling requirements are met. 

Proprietary solvents may be repackaged for retail, wholesale, and industrial sales. Retail sales of special industrial solvents are prohibited. Agents may repackage special industrial solvents for wholesale and industrial sales, but only in dmm quantities and with the producer s label. Special labeling requirements of the BATE apply to both proprietary and special industrial solvents. 

Occasionally, a small clean-up of a few tons may occur. These are usually handled via placing the waste in open-topped drums that are sealed with a hd and ring closure. Consultation with the ultimate treatment facihty is important to select the correct drum size and material and eliminate the need for repackaging the waste. 

Size reduction, separation, agglomeration, packaging/repackaging, and others or... 

Are the ABC Co. products currently contracted for manufacture or repackaging specifically listed m the contractual agreement (Please attach a list of pounds received and shipped of ABC Co. owned raw materials, intermediates and finished products for the last twelve months.) ... 

Process the Tie. -TlAsa formulation f y1 As an article chemical XJ As a reactant b.L J component Jcomponent d. [ ] Repackaging only ... 

Please also note that If you repackage or otherwise redistribute this product to industhal customers, a notice similar to this one should be sent to those customers. 

An association of chemical distributor companies that purchase and take title to chemical products from manufacturers. They then formulate, blend, repackage, warehouse, transport and marPet these chemicals to their customers. 

Anhydrous HF was first produced commercially in the USA in 1931 and in the UK from about 1942. By 1992 some eighteen countries were each producing at least 3000 tonnes pa with North America accounting for some 330000 tonnes of the estimated annual world production of about 875 000 tormes, A further 205 000 tonnes was used captively for production of AIF3. Price in 1990 was about l.50/kg for the anhydrous acid and somewhat less for 70% acid. The primary suppliers ship HF in tank-cars of 20-91-tonne capacity and the product is also repackaged in steel cylinders holding 8.0-900 kg (2.7-635 kg in the UK). Lecture bottles contain 340 g HF. The 70% acid is shipped in tank-cars of 32-80-tonne capacity, tank trucks of 20-tonne capacity, and in polyethylene-lined drums holding 114 or 208 I,... 

Another common practice in hospitals is the repackaging of products purchased in bulk into smaller containers. Increased handling ofthe product inevitably increases the risk of contamination, as shown by one survey when hospital-repacked items were found to be contaminated twice as often as those in the original pack (Public Health Laboratory Service Report 1971). 

Both intact carotenoids and their apolar metabolites (retinyl esters) are secreted into the lymphatic system associated with CMs. In the blood circulation, CM particles undergo lipolysis, catalyzed by a lipoprotein lipase, resulting in the formation of CM remnants that are quickly taken up by the liver. In the liver, the remnant-associated carotenoid can be either (1) metabolized into vitamin A and other metabolites, (2) stored, (3) secreted with the bile, or (4) repackaged and released with VLDL particles. In the bloodstream, VLDLs are transformed to LDLs, and then HDLs by delipidation and the carotenoids associated with the lipoprotein particles are finally distributed to extrahepatic tissues (Figure 3.2.2). Time-course studies focusing on carotenoid appearances in different lipoprotein fractions after ingestion showed that CM carotenoid levels peak early (4 to 8 hr) whereas LDL and HDL carotenoid levels reach peaks later (16 to 24 hr). 

Chapter 1146 Packaging Practice—Repackaging a Single, Solid, Oral Drug Product into a Unit Dose Container... 

The term remanufactured product means a rechargeable consumer product that has been altered by the replacement of parts, repackaged, or repaired after initial sale by the original manufacturer. 

Once returned to the presynaptic terminal, dopamine is repackaged into synaptic vesicles via the vesicular monoamine transporter (VMAT) or metabolized to dihydroxyphenylacetic acid (DOPAC) by monoamine oxidase (MAO). Two alternative pathways are available for dopamine catabolism in the synapse, depending on whether the first step is catalyzed by MAO or catechol-O-methyltransferase (COMT). Thus, dopamine can be either deaminated to 3,4-dihydroxyphenylacetic acid (DOPAC) or methylated to 3-methoxytyramine (3-MT). In turn, deamination of 3-MT and methylation of DOPAC leads to homovanillic acid (HVA). In humans, cerebrospinal fluid levels of HVA have been used as a proxy for levels of dopaminergic activity within the brain (Stanley et al. 1985). 

Market approval authority CDRH, using device authorities is responsible for the kit if the manufacturer is repackaging a market drug. Responsibility for overall packaging resides with CDRH. CDER will be consulted as necessary on the use of drug authorities for the repackaged drug component. 

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