Renal tubular obstruction, drug-induced

Since intratubular hydrostatic pressure does not differ significantly from controls in euvolemic and volume expanded animals, it is unlikely that intratubular obstruction plays an important role in early, cispl-atin-induced acute renal failure. Following withdrawal of the drug, renal insufficiency stabilizes but remains indefinitely impaired. The cisplatin-induced hypofil-tration is usually associated with tubular proteinuria. Severe salt-wasting with orthostatic hypotension has been observed after cisplatin administration in a minority of patients [18]. 

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