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Effects of Renal Disease on Drug Absorption

The paucity of reliable bioavailability data in patients with impaired renal function underscores the cumbersome nature of most absolute bioavailability studies in which oral and intravenous drug doses are administered on two separate occasions. The validity of this approach rests on the assumption that the kinetics of drug distribution and elimination remain [Pg.56]

Yacobi A, Batra VK, Desjardins RE, Faulkner RD, Nicolau G, Pool WR, Shah A, Tonelli AP. Implementation of an effective pharmacokinetics research program in industry. In Yacobi A, Skelly JP, Shah VP, Benet LZ, eds. Integration of pharmacokinetics, pharmacodynamics, and toxicokinetics in rational drug development. New York Plenum 1993. p.125-35. [Pg.57]

Spyker DA, Harvey ED, Harvey BE, Harvey AM, Rumack BH, Peck CC, Atkinson AJ Jr, Woosley RL, Abernethy DR, Cantilena LR. Assessment and reporting of clinical pharmacology information in drug labeling. Clin Pharmacol Ther 2000 67 196-200. [Pg.57]

Lesar TS, Briceland L, Stein DS. Factors related to errors in medication prescribing. JAMA 1997 277 312-7. [Pg.57]


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