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Renal effects therapeutic drug monitoring

Myre SA, McCann J, First MR, Cluxton RJ, Jr. Effect oftrimethoprim on serum creatinine in healthy and chronic renal failure volunteers. Therapeutic drug monitoring. 1987 Jun 9(2) 161-5. [Pg.373]

Pacifici, G.M., Viani, A., Taddeuci-Brunelli, G. et al. (1986) Effects of development, ageing, and renal and hepatic insufficiency as well as hemodialysis on the plasma concentrations of albumin and ai-acid glycoprotein implication for binding of drugs. Therapeutic Drug Monitoring, 8, 259-263. [Pg.133]

The steady-state maximum plasma concentration, Cmaxss, of gentamycin and tobramycin are 6 to 10 mcg/mL. The Cmax ss of amikacin is 25 to 30 mcg/mL. The Cmin ss of both gentamycin and tobramycin is 0.5 to 1.5 mcg/mL, while that of amikacin is 5 to 8 mcg/mL. In order for these drugs to be effective, it is important to closely monitor their therapeutic concentrations. An important observation of these antibiotics is that with prolonged therapy, the Cminsl, values increase. This increase is due to the renal impairment. In the case where Cmin ss is less than the desired Cmin ss, the dose may be insufficient. [Pg.280]

Theophylline is a classic example. Its bronchodi-lator effects are related to plasma concentrations in the range of 5-20 mg l-1, while higher concentrations are associated with tachyarrythmias and other serious adverse effects. This is a drug with a narrow therapeutic window . Elderly patients commonly have several risk factors that can lead to unexpectedly high serum concentrations after administration of standard doses reductions in renal clearance, reduced volume of distribution and an increased probability of concomitant disease and other therapies (Ohnishi et al., 2003). Monitoring plasma levels is thus helpful in avoiding the adverse effects of theophylline. [Pg.376]


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