Adverse drug reactions impaired renal function

Elderly Fenofibric acid is known to be substantially excreted by the kidney, and the risk of adverse reactions to this drug may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, take care in dose selection. 

Penicillins are rapidly eliminated, particularly by glomerular filtration and renal tubular secretion, With some (e.g, cloxacillin), metabolic transformation occurs, especially in anuric patients, When renal function is impaired, 7-10% of the antibiotic will be inactivated by the liver per hour. Adverse drug reactions are ... 

The Austrian Adverse Drug Reactions Advisory Committee received three reports of severe electroljde disturbances associated with an oral bowel-cleansing solution containing sodium phosphate solution (Fleet Phospho-Soda Buffered Saline Laxative Mixture), used as a bowel preparation for colonoscopy (5). Prescribers are advised to be aware of complications of the use of phosphate enemas, particularly in infants, elderly or debilitated patients, patients with congestive heart failure, and patients with impaired renal function. 

Older adults are at increased risk for adverse reactions from the antineoplastic drugs because of the increased incidence of chronic disease, particularly renal impairment or cardiovascular disease. When renal impairment is present, a lower dosage of the antineoplastic may be indicated. Creatinine clearance isused to monitor renal function in the older adult. Blood creatinine levels are likely to be inaccurate because of a decreased muscle mass in the older adult. 

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