Drug absorption, pharmacokinetic renal disease

Diseases such as hepatic or renal diseases can influence the incidence of ADRs by altering the pharmacokinetics of drugs, such as absorption, distribution, metabolism, or excretion. 

Clearance. This usually refers to the total plasm clearance (or total whole blood clearance) afte infravenous administration. In some instances the total clearance afrer an oral dose has been included if the drug is known to be well absorbed and is no subject to significant first-pass metabohsm. Numerous factors and intersubject variations ma affect the absorption, distribution, metabohsm, and excretion of drugs. These include age, sex, and disease states such as renal impairment In additior results of analyses may be subject to imavoidable analytical inaccuracies. Consequently, friere may beconsiderable variations in the observed drug concentrations and in values for pharmacokinetic... 

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