Regulatory criteria

Conder JM, Hoke RA, de Wolf W, Russel MH, Buck RC (2008) Are PFCAs bioaccumulative A critical review and comparison with regulatory criteria and persistent lipophilic compounds. Environ Sci Technol 42 995-1003... 

Because component-based analysis of PCBs has limited the usefulness of the historical database for current environmental research and in formulation of regulatory criteria, procedures were... 

When sampling in the enviromnent, it is often impossible to determine which chemical mixtures are causing a total petroleum hydrocarbons reading, which is one of the major weaknesses of the method. At minimum, before using contaminants data from diverse somces, efforts should be made to determine that field collection methods, detection limits, and quality control techniques were acceptable and comparable. This will help the analysts compare the analysis in the concentration range with the benchmark or regulatory criteria concentrations should be very precise and accmate. 

Final waste form satisfies Nuclear Regulatory Commission and U.S. Environmental Protection Agency (EPA) regulatory criteria for disposal. 

The possible carcinogenic hazards from synthetic pesticides are minimal compared to the background of nature s pesticides, though neither may be a hazard at the low doses consumed. Analysis also indicates that many ordinary foods would not pass the regulatory criteria used for synthetic chemicals. Caution is necessary in drawing conclusions about the occurrence in the diet of natural chemicals that are rodent carcinogens. These di-... 

There is little doubt that intrepid entrepreneurs will continue to champion ideas for the application of ionic liquids. Without a doubt, further uses of these materials will be found and justified for commercial use. However, the perceived disadvantages, and particularly the toxicity issues, will temper enthusiasm until the data obtained provide reassurances that an ionic-liquid-based process satisfies all the economic, toxicological, safety, and (in the pharmaceutical industry) FDA regulatory criteria to justify implementation. 

Table 8.5 Regulatory criteria of chemical substance under The amended Chemical Substances Control Law in Japan ...

Major factors influencing design (Figure 2) were identified as regulatory criteria, operational capabilities, current state of the art, and agent criteria. 

Regulatory criteria as provided in the DARCOM Safety Manual, DARCOM Safety Regulations for Chemical Agents, DOD Ammunition and Safety Standards and the Army Chemical Surety Program were found to have a significant impact on facility design. 

Regulatory Criteria. Some organizations use regulatory information to determine which facilities will participate in the metrics system. The logic is if a facility is covered by a process safety-focused regulation, then that... 

This entry is intended to provide an introduction and practical analysis of the current standardized aspects of aquatic toxicity biomonitoring of industrial and municipal effluents. These tests and monitoring programs are needed to determine whether management requirements or regulatory criteria are being met as well as to assess the temporal and spatial trends in water quality. 

Noncarcinogenic Effects. These effects are assessed only if the carcinogenic indicator compounds are not detected or are below regulatory criteria. The following petroleum hydrocarbon fractions, minus the carcinogenic indicator compounds, were selected as representing compounds with similar transport properties. Toxicity values for constituents of the fraction or for a similar mixture were selected to represent the toxicity of the fraction. Aromatic and aliphatic hydrocarbons are considered separately and further subdivided on the basis of equivalent carbon number index (EC). This index is equivalent to the retention time of the compounds on a boiling point GC column (non-polar capillary column), normalized to the //-alkanes. Physical and chemical properties of hydrocarbons that are... 

Long-term solutions that meet regulatory criteria are needed for waste storage. There are currently no... 

FIGURE 46.8 Regulatory criteria for granting a biowaiver nsing an IVIVC. The npper of the two profiles is for the test formnlation, and the lower of the two profiles is for the reference formulation. NMT = no more than. 

Source documents are composed of hospital records, office charts, laboratory data sheets, subject diaries, pharmacy dispensing records, recorded data from automated instruments, x-rays, etc. Source documents should be legible and should document that the subject is participating in a clinical trial. Some of the key areas to cross reference source documents to case report forms and regulatory criteria are the informed consent process, inclusion/exclusion criteria, adverse experiences, investigational product administration, concomitant medications administered to the subject during the trial, withdrawal from the study for any reason, and subjects lost to follow-up. 

In 1981, the Army conducted a pilot-scale study of UV oxidation for treating waters from the Kansas AAP contaminated with RDX. RDX concentrations in the process water ranged from 0.8 to 21.0 mg/l. The UV oxidation system consisted of thirty 40-watt, UV lamps, and an ozone generator, which provided ozone to the treatment process. Treatment times in this system ranged from 37 to 375 minutes at flow rates of 0.2 to 2.0 gpm. Final RDX concentrations in the effluent ranged from 0.1 to 1.7 mg/ , which would not have met current regulatory criteria. 

The data user must know the CLP procedures before accurate interpretations can be made. Differences exist between "CLP Total values and regulatory criteria values such as "Total Recoverable". 

Phytoextraction has the potential to remediate many metal and radionuclide contaminated sites using a less invasive form of treatment than traditional methods such as escavation and disposal. There are four factors that influence or determine the ability of phytoextraction to effectively remediate a metal contaminated site 1). Site arability and plant biomass yields 2) metal solubility and availability for uptake 3) the ability of the plant to accumulate metals in the harvestable plant tissues and 4) regulatory criteria. 

TABLE 1.3-12. Regulatory Criteria for Biosimilar Products or Follow-Ou Biologies... 

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