Foreign-body response

The first synthetic polyglycoHc acid suture was introduced in 1970 with great success (21). This is because synthetic polymers are preferable to natural polymers since greater control over uniformity and mechanical properties are obtainable. The foreign body response to synthetic polymer absorption generally is quite predictable whereas catgut absorption is variable and usually produces a more intense inflammatory reaction (22). This greater tissue compatibihty is cmcial when the implant must serve as an inert, mechanical device prior to bioresorption. 

Anderson JM. Inflammation and the foreign body response. Prob Gen Surg 1994 11 147-160. 

Norton LW, Koschwanez HE, Wisniewski NA, Klitzman B, Reichert WM. Vascular endothelial growth factor and dexamethasone release from nonfouling sensor coatings affect the foreign body response. Journal of Biomedical Materials Research. Part A 2007, 81, 858-869. 

Ward WK, Slobodzian EP, Tiekotter KL, Wood MD. The effect of microgeometry, implant thickness and polyurethane chemistry on the foreign body response to subcutaneous implants. Biomaterials 2002, 23, 4185-4192. 

Mou X. Modulation of foreign body response towards implanted microdialysis sampling probes. Ph.D. Dissertation. Rensselaer Polytechnic Institute, 2007. 

Hetrick EM, Prichard HL, Klitzman B, Schoenfisch MH. Reduced foreign body response at nitric oxide-releasing subcutaneous implants. Biomaterials 2007, 28, 4571 -580. 

De Scheerder I, Wang K, Wilczek K, et al, Local methylpred-nisolone inhibition of foreign body response to coated intracoronary stents, Coronary Artery Dis 1996 7 161-166. Baker J, Nikolaychik V Zulich A, et al, Fibrin coated stents as depot to deliver RGD peptide inhibit vascular reaction in atherosclerosis rabbit model [abstr], J Am Coll Cardiol I 996 27 197A,... 

A possible technique adopted to prevent fibrous capsule formation around the implant is the addition of a tissue intermediary [203,204]. Indeed, if this material has a continuous, interconnected, porous structure (pore diameter >8-10 p-m), macrophages are capable of invading structure voids. Consequently, vascularized tissue can grow in the implant and the foreign body response is avoided as this porous stmcture is able to mimic extracellular matrix. The first example of intermediary tissue use concerns the coating of an implanted catheter by means of a silicone mbber cage [205]. Typically,... 

The foreign body response to carbon fibers is not chronic unless they fragment. One major problem has been the accumulation of wear debris near the acetabular components [129]. However, when used as ligament replacements, carbon fibers appear to induce a type of fibrosis in which collagen fibers align with the fibers. This suggests that carbon fibers can be used as a template for the formation of fibrous tissue [130] and indeed tendon fibroblast cells have been grown on a... 

Although the pathogenesis of dprofloxacin-induced acute interstihal nephritis is not clear, it has been attributed to an inflammatory interstitial response secondary to the crystalluria associated with the quinolone (foreign body response) [232, 238, 248]. Crystalluria and the presence of crystals of dprofloxacinin the renal tissue have been shown in animal experiments. The species studied (rats, monkeys, dogs), however, have alkaline urine, and because the quinolone solubihty is... 

See also Foreign Body Response Implant Studies. 

Kyriakides TR and Bornstein P (2003) Matricellular proteins as modulators of wound healing and the foreign body response. Thrombosis and Haemostasis 90 986-992. 

Foreign Body Response, Pages 367-369, Shayne C. Gad SummaryPlus Full Text + Links PDF (57 K)... 

Onuki, Y., Bhardwaj, U., Papadimitrakopoulos, F., and Burgess, D.J. (2008) A review of the biocompatibility of implantable devices current challenges to overcome foreign body response. Journal of Diabetes Science and Technology, 2 (6), 1003-1015. 

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