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Pigs, transgenic

In addition to milk, a range of recombinant proteins have been expressed in various other targeted tissues/fluids of transgenic animals. Antibodies and other proteins have been produced in the blood of transgenic pigs and rabbits. This mode of production, however, is unlikely to be pursued industrially for a number of reasons ... [Pg.115]

Bengel EM, Anton M, Richter T, Simoes MV, Haubner R, Henke J et al. Noninvasive imaging of transgene expression by use of positron emission tomography in a pig model of myocardial gene tmnsfer. Circulation 2003 108 2127-2133... [Pg.37]

Transgenic pig. rabbit, and sheep by micro injection of foreign DNA iiitu egg nuclei. [Pg.213]

Figure 13.6 Production of a transgenic pig to produce a human protein. Figure 13.6 Production of a transgenic pig to produce a human protein.
Carcinogenicity Tg.rasH2 transgenic mouse model Other antigenicity in guinea pigs, mice, and rats tumor cell lines (effects of the product on proliferation) human tumor xenografts in athymic nude mice hemolytic potential studies... [Pg.1062]

Mammalian in vivo models are the closest approximation to clinical situations and allow for the most conclusive translational hypothesis. Nevertheless, species differences exist in susceptibility to drugs, in particular, to AG antibiotics. Of note, the guinea pig has a very good track record of reflecting AG ototoxicity as seen in patients, and rodent models as such offer extensive research opportunities through the availability of molecular tools and transgenic animals. [Pg.213]

Transgenic animals Complex posttranslational processing not done by cell culture Sheep, goats, and pigs Development in its infancy Regulation issues Transfer of disease/virus... [Pg.942]

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See also in sourсe #XX -- [ Pg.233 , Pg.237 , Pg.238 ]



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