G protein-coupled receptor structure

Kobilka BKG (2006) G protein coupled receptor structure and activation. Biochim Biophys Acta... 

Visiers, I., Ballesteros, J. A., and Weinstein, H. (2002) Three-dimensional representations of G protein-coupled receptor structures and mechanisms. Methods Enzymol 343, 329-371. 

G-protein-coupled receptors structure-activity relationships... 

Gudermann, T., Nurnberg, B., and Schultz, G. Receptors and G proteins as primary components of transmembrane signal transduction. Part 1. G-protein-coupled receptors structure and function./. Mol. Med. 1995, 73, 51-63. 

Mierke, D.F. and Giragossian, C. (2001) Peptide hormone binding to G-protein-coupled receptors Structural characterization via NMR techniques. Med. Res. Rev. 21 450-471. 

Haga, T. and Takeda, S. (2005) G-Protein Coupled receptors Structure, Function and Ligand Screening Taylor and Frances, Boca Raton, FL. 

X. Ding, X. Zhao and A. Watts, G-Protein-Coupled Receptor Structure, Ligand Binding and Activation as Studied by Solid-State NMR Spectroscopy, Biochem. /., 2013, 450, 443. 

Cotecchia S et al (2004) Structural determinants involved in the activation and regulation of G protein-coupled receptors lessons from the ai -adrenergic receptor sub-types. Biol Cell 96 327-333... 

Frizzled (Fz) proteins comprise a family of seven-pass transmembrane receptors with a cysteine-rich extracellular domain. As a class, Fz proteins are structurally related to the superfamily ofheterotrimeric G-protein coupled receptors (GPCRs). Diere are 4 Fz genes in Drosophila and 10 in humans, with close orthologs... 

Alike any other G-protein coupled receptors (GPCRs), mGlu receptors have seven transmembrane helices, also known as the heptahelical domain (Fig. 2). As observed for all GPCRs, the intracellular loops 2 and 3 as well as the C-terminal tail are the key determinants for the interaction with and activation of G-proteins. However, sequence similarity analysis as well as specific structural features make these mGlu receptors different from many other... 

Muscarinic acetylcholine receptors (mAChRs) form a class of cell surface receptors that are activated upon binding of the neurotransmitter, acetylcholine. Structurally and functionally, mAChRs are prototypical members of the superfamily of G protein-coupled receptors. Following acetylcholine binding, the activated mAChRs interact with distinct classes of heterotrimeric G proteins resulting in the activation or inhibition of distinct downstream signaling cascades. 

Sensory receptors that structurally and functionally belong to the G protein coupled receptor superfamily. Olfactory receptors are a large GPCR family with >300 members in human that are expressed in neurons of the nasal olfactory epithelium where they sense mostly volatile olfactory molecule. The overall number of olfactory receptors differs widely between species and an expansion of different recqrtors is in particular obvious in species that depend on their olfactory sense for survival. 

Bondensgaard K, Ankersen M, Thogersen H, Hansen BS, Wulff BS, Bywater RP. Recognition of privileged structures by G-protein coupled receptors. J Med Chem 2004 47 888-99. 

Cavasotto C, Orry AJW, Abagyan R A. Strnctnre-based identification of binding sites, native ligands and potential inhibitors for G-protein coupled receptors. Proteins Structure Funct Genet 2003 51 423-33. 

Chemokines are small chemotactic cytokines that act as important messenger molecules between cells of the immune system. Chemokines produce their effects by activating a family of G-protein-coupled receptors. Chemokine receptors are all seven-transmembrane glycoproteins that are structurally related. They may be characterized into those that bind to specific ligands, or those that bind several chemokine ligands. There are also virally encoded (viral) chemokine receptors that represent shared receptors that have been transduced into the viral genome during evolutionary history (Premack and SchaU 1996). 

Feng Y, Broder CC, Kennedy PE, Berger EA (1996) HIV-1 entry cofactor functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science 272 872-877 Fernandez EJ, LoUs E (2002) Structure, function, and inhibition of chemokines. Annu Rev Pharmacol Toxicol 42 469-499... 

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