Receptors, for saccharides

Porphyrin-based diboronic acids as artificial receptors for saccharides 98YGK831. 

Finally, a huge number of different boronic and diboronic acids has been designed with the aim to use them as molecular receptors for saccharide... 

Figure 16 l,l -Binaphthyl-substituted macrocycles as receptors for saccharide recognition based on the idea of a picket-fence porphyrin. 

Boronic acids form reversible complexes with vicinal diols in aqueous media as shown below. This strategy has been incorporated into receptors for saccharides. It typically takes a few minutes for these equilibria to be achieved in solution. Given this simple observation, do you expect the study of these binding events to be on the slow or fast exchange time scale on a 300 MHz H N MR spectrometer Do you exjject to see different resonances for the boronic acid and the boronate ester, or an average of the signals Explain your answer. 

Some general observations concerning boronic add-based saccharide receptors were summarised at the end of Chapter 4. We believe that those observations will help other research groups design new boronic-based receptors for saccharides. Therefore, we will recap some of the more salient points here. 

Lumophore-spacer-receptor systems are not by any means limited to the ami-noalkyl aromatic family even if we focus on the receptor unit. Still, the latter family is likely to remain a major provider of ionically switchable luminescent devices. Aminoalkyl aromatics also serve as the platform for the development of luminescent PET sensors for a whole class of nonionic saccharides. While aliphatic amines, either singly or in arrays, can serve as receptors for a variety of cationic... 

James, T.D. (2005) Boronic Acid-Based Receptors and Sensors For Saccharides, in Boronic Acids (ed. D.G. Hall), Wiley-VCH, Weinheim, Ch. 12,... 

Membranes and Molecular Assemblies The Synkinetic Approach 6 Calixarenes Revisited 7 Self-assembly in Supramolecular Systems 8 Anion Receptor Chemistry 9 Boronic Acids in Saccharide Recognition 10 Calixarenes An Introduction, 2nd Edition 11 Polymeric and Self Assembled Hydrogels From Fundamental Understanding to Applications 12 Molecular Logic-based Computation 13 Supramolecular Systems in Biomedical Fields 14 Synthetic Receptors for Biomolecules Design Principles and Applications... 

In the design of boronic acid-based sensor systems, it has been established that two receptor units are required if saccharide selectivity is to be achieved." " Retaining the same dual boronic acid recognition units throughout, a modular system in which the linker and fluorophore units of these sensors could be modified independently needed to be developed. The use of modular or core scaffolds for saccharide recognition has been championed by James, 3ng,i 1-82 5 Hall, and Singaram. i... 

Electrochemical detection of saccharides by enzymatic decomposition of saccharides is the basis of most current commercial o-glucose biosensors.The development of boronic acid-based electroactive saccharide receptors for D-glucose is also possible. However, the main value of the boronic acid-based synthetic systems is that they can provide selectivity for a range of saccharides other than D-glucose. 

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