Synthetic receptor

Macroheterocycles as synthetic receptors for steroids in molecular recognition 97CRV1567. 

Porphyrin-based synthetic receptors for ubiquinone and cytochrome C 98YGK745. 

Progress in molecular recognition of functionalized calixarenes with hetero-atomic bridges as synthetic receptors 99MI43. 

Metal-directed self-assembly of two- and three-dimensional synthetic receptors (macroheterocycles involving transition metal atoms, among them chelated atoms) 98CSR417. 

MacrocycHc isophthalamides (the tetralactam macrocycles) have been used as a host to build rotaxanes and catenanes by Vogtle and others [15]. Structurally analogous to cyclophanes, their initial usage as a synthetic receptor was for... 

Furthermore, all the examples shown above in Sects. 4.1-4.3 emphasize the significance of both steric and functional features in selective crystallizations. The latter are needed not only for binding between the individual host and guest constituents, but also for effecting a continuous and relatively unflexible pattern of intermolecular arrangement in the crystal lattice. This observation appears to be a very useful one in the systematic design of novel clathrate-based synthetic receptors. 

The synthesis of bis(triazine) molecules capable of acting as synthetic receptors for barbiturate guest molecules has been described <06EJO1444>. 

Synthetic products, sulfur use in, 23 591 Synthetic pulps, 16 96 Synthetic pyridines, 21 116, 118 Synthetic receptors, 3 808-810 Synthetic research... 

Ghosh K, Sarkar AR, Patra A (2009) Pyridinium amide-based simple synthetic receptor for selective recognition of dihydrogenphosphate. Tetrahedron Lett 50 6557-6561... 

Higher differences for the interaction of both the biological and the synthetic receptors with the two enantiomers are found for the propanol-derivatives than for the ethanol-derivatives (Norephedrine, Metaraminol vs. Octopamime, Noradenaline Pseudoephedrine, Ephe-drine vs. Synephrine, Adrenaline). 

Gasparrini, F. et al.. Natural and totally synthetic receptors in the innovative design of HPLC chiral stationary phases. Pure Appl. Chem., 75, 407, 2003. 

Otto S, Severin K (2007) Dynamic Combinatorial Libraries for the Development of Synthetic Receptors and Sensors. 277 267-288... 

Dougherty, D.A. and Staueeer, D.A. Acetylcholine binding by a synthetic receptor implications for biological recognition. Science. 1990, 250, 1558-1560. 

Still, W. C. Discovery of sequence-selective peptide binding by synthetic receptors using encoded combinatorial libraries. Acc. Chem. Res. 1996,29,155-163. 

Corbett, P. T Sanders, J. K. M. Otto, S. Exploring the relation between amplification and binding in dynamic combinatorial libraries of macrocyclic synthetic receptors in water. Chem. Eur. J. 2008,14, 2153-2166. 

The application of biosensors for process monitoring has been dogged by problems with fouling, selectivity, degrading bioactivity and long-term stability. Recent developments in molecularly imprinted polymers (MIPs) show some promise as synthetic receptors and have been used for this purpose for assays and as HPLC stationary phases. Recent work has shown that MIPs show increased robustness, storage endurance and lower cost compared with biosensors, which... 

Soon thereafter, chirality was recognized as a necessary and indispensible part of synthetic receptor molecule design and function. Predictably, not only has nature s chiral pool been called upon to supply inexpensive and readily available sources of chirality, but the ability of the chemist to resolve optically active precursors from racemic modifications prepared in the laboratory has been exploited ingeniously in a number of different directions. The various elements of chirality centers, axes, planes, as well as helices, have been incorporated into both axially symmetric and asymmetric receptors. 

The Na or K cation interaction has been experimentally probed by using synthetic receptors that comprise diaza-18-crown-6 lariat ethers having ethylene side arms attached to aromatic donors. (Adapted from Meadows et al., 2001)... 

Kato Y, Conn MM, Rebek J. Hydrogen-bonding in water using synthetic receptors. Ptoc Natl Acad Sci USA 1995 92 1208-1212. 

Tomeiro M, Still WC. Sequence-selective binding of peptides in water by a synthetic receptor molecule. J Am Chem Soc 1995 117 5887-5888. 

Dickert FL, Hayden O, Halikias KP. Synthetic receptors as sensor coatings for molecules and living cells. Analyst 2001 126 766-771. 

Ramanaviciene A, Ramanavicius A. Molecularly imprinted polypyrrole-based synthetic receptor for direct detection of bovine leukemia virus glycoproteins. Biosens Bioelectron 2004 20 1076-1082. 

Schrader T, Hamilton AD. Functional synthetic receptors. Weinheim Wiley-VCH 2005. 

Compounds of this type are extremely important as they can be used for the preparation of catalytic antibodies, synthetic receptors, and model compounds for the investigation of the DNA lesion and recognition steps and DNA repair mechanisms (see Section 10.23.12). 

The goal in Volume 4 of Advances in Supramolecular Chemistry remains the same as for previous volumes to present a broad range of supramolecular science recorded by an international panel of distinguished researchers. Contributions in this volume span the scientific range from electronic device development to novel synthetic receptor molecules to biomimetic ion channels. 

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