Receptors chemo

Besides the arterial baroreceptors, central projections from other inputs, for example cardiac mecha-no-receptors, chemo-receptors, pulmonary stretch receptors, and somatic inputs, are capable of influencing the controlling system and thereby the autonomic effectors. 

Daelemans, D., Schols, D., Witvrouw, M., Rannecouque, C., Hatse, S., Door-EN, S.V., Hamy, F., Klimkait, X, Clercq, E.D., and Vandamme, A.-M. A second target for the peptoid Xat/transactivation response element inhibitor CGP64222 Inhibition of human immunodeficiency virus replication by blocking CXC-chemo-kine receptor 4-mediated virus entry. 

Ajami K, Pitman MR, Wilson CH et al (2008) Stromal cell-derived factors lalpha and Ibeta, inflammatory protein-10 and interferon-inducible T cell chemo-attractant are novel substrates of dipeptidyl peptidase 8. FEBS Lett 582 819-825 Albright AV, Shieh JT, O Connor Ml et al (2000) Characterization of cultured microglia that can be infected by HIV-1. J Neurovirol 6(Suppl 1) S53-S60 Allen SJ, Crown SE, Handel TM (2007) Chemokine receptor structure, interactions, and antagonism. Annu Rev Immunol 25 787-820... 

Clark-Lewis I, Schumacher C, Baggiofini M, Moser B. Structure-activity relationships of interleukin-8 determined using chemically synthesized analogs. Critical role of NH2-terminal residues and evidence for uncoupling of neutrophil chemo-taxis, exocytosis, and receptor binding activities. J Biol Chem 1991 266 23128-34. 

The literature on chemokines in transplantation has been extensively reviewed in recent years (7-9). In this chapter, we focus on a limited number of chemo-kine receptors where evidence for a functional role has been verified. From the plethora of chemokine receptors, this has been demonstrated for CXCR1/2 in reperfusion injury and for CCR1, CCR5, and CXCR3 during acute and chronic allograft rejection. 

Haringman JJ, Smeets TJ, Reinders-Blankert P, Tak PP. Chemokine and chemo-kine receptor expression in paired peripheral blood mononuclear cells and synovial tissue of patients with rheumatoid arthritis, osteoarthritis, and reactive arthritis. Ann Rheum Dis 2006 65(3) 294-300. 

Stantchev TS, Broder CC. Human immunodeficiency virus type-1 and chemo-kines beyond competition for common cellular receptors. Cytokine Growth Factor Rev 2001 12(2-3) 219-243. 

Wang JM, Oppenheim JJ. Interference with the signaling capacity of CC chemo-kine receptor 5 can compromise its role as an HIV-1 entry coreceptor in primary T lymphocytes. J Exp Med 1999 190(5) 591-595. 

Leukotriene B4 has been implicated in inflammatory processes and chemo-taxis. The G-protein-coupled receptor in human myeloid cells was postulated to possess two distinct binding sites. Photoaffinity studies using unmodified tritiated LTB4 as photoreactive species labeled two different proteins in the presence (53 kDa) and in the absence of a non-cleavable GTP analogue (56 kDa). This means that stabilization of the G-protein in the GTP-bound state resulted in an interconversion of the first high affinity binding site to an alternative low-affinity binding site [99]. 

In an immunosensor the core-cover interface of an optical waveguide structure is coated with a chemo-optical transducer receptor layer, which can selectively bind to specific analyte molecules present in the cover medium. The receptor-analyte reaction obeys the law of mass action, which states that the rate of a reaction is proportional to the concentration of the reactants. At equilibrium, the rate of formation of the receptor-analyte complex is equal to the rate of breaking, and the equilibrium constant, K. can be written as... 

The uPA receptor also appears to play a role in cell locomotion and chemo-taxis, at least for human monocytes in vitro (G8). Using these cells, chemotaxis was inhibited by pretreatment with both anti-uPA receptor antibodies and anti-sense uPA receptor oligonucleotides. Expression of uPA catalytic activity was not required for chemotaxis with this cell type (G8). 

Hirai, H., Tanaka, K., Yoshie, O., et al. (2001) Prostaglandin selectively induces chemo-taxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2. J. Exp. Med. 193, 255-261. 

Aprepitant (Emend) [Centrally Acting Antiemetic] Uses Pre-vents N/V assoc w/ emetogenic CA chemo (eg, cisplatin) (use in combo w/ other antiemetics) Action Substance P/neurokinin l(NKi) receptor antagonist Dose 125 mg PO day 1, 1 h before chemo, then 80 mg PO qAM days 2 3 Caution [B, /-] Contra Use w/ pimozide, Disp Caps SE Fatigue, asthenia, hiccups Interactions T Effects W/ clarithromycin, diltiazem, itraconazole, ketoconazole, nefazodone, nelfinavir, ritonavir, troleandomycin T effects OF alprazolam, astem-izole, cisapride, dexamethasone, methylprednisolone, midazolam, pimozide, terfe-nadine, triazolam, chemo agents, eg, docetaxel, etoposide, ifosfamide, imatinib, irinotecan, paclitaxel, vinblastine, vincristine, vinorelbine i effects W/ paroxetine,... 

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