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Reaction schemes synthesis

Some systematic studies on the different reaction schemes and how they are realized in organic reactions were performed some time ago [18]. Reactions used in organic synthesis were analyzed thoroughly in order to identify which reaction schemes occur. The analysis was restricted to reactions that shift electrons in pairs, as either a bonding or a free electron pair. Thus, only polar or heteiolytic and concerted reactions were considered. However, it must be emphasized that the reaction schemes list only the overall change in the distribution of bonds and ftee electron pairs, and make no specific statements on a reaction mechanism. Thus, reactions that proceed mechanistically through homolysis might be included in the overall reaction scheme. [Pg.188]

Clearly, for symmetry reasons, the reverse process should also be considered. In fact, early versions of our reaction prediction and synthesis design system EROS [21] contained the reaction schemes of Figures 3-13, 3-15, and 3-16 and the reverse of the scheme shown in Figure 3-16. These four reaction schemes and their combined application include the majority of reactions observed in organic chemistry. Figure 3-17 shows a consecutive application of the reaction schemes of Figures 3-16 and 3-13 to model the oxidation of thioethers to sulfoxides. [Pg.191]

In principal, synthesis route prediction can be done from scratch based on molecular calculations. However, this is a very difficult task since there are so many possible side reactions and no automated method for predicting all possible products for a given set of reactants. With a large amount of work by an experienced chemist, this can be done but the difficulty involved makes it seldom justified over more traditional noncomputational methods. Ideally, known reactions should be used before attempting to develop unknown reactions. Also, the ability to suggest reasonable protective groups will make the reaction scheme more feasible. [Pg.277]

The replacement of selenoamide by selenourea in the Hantzsch s synthesis. (1st method) leads to 2-aminoselenazoles 2, 14. 15). This series of compounds has been well developed, mainlv because selenourea is much more easily accessible than the selenoamides, but also because a wide variety of a-halogenated carbonyl compounds are available for the Hantzsch s evdization reaction (Scheme 5). 2-Aminoselenazole itself was prepared from commercially available chloroacetaldehyde semihydrate... [Pg.222]

Covalent synthesis of complex molecules involves the reactive assembly of many atoms into subunits with aid of reagents and estabUshed as well as innovative reaction pathways. These subunits are then subjected to various reactions that will assemble the target molecule. These reaction schemes involve the protection of certain sensitive parts of the molecule while other parts are being reacted. Very complex molecules can be synthesized in this manner. A prime example of the success of this approach is the total synthesis of palytoxin, a poisonous substance found in marine soft corals (35). Other complex molecules synthesized by sequential addition of atoms and blocks of atoms include vitamin potentially anticancer KH-1 adenocarcinoma antigen,... [Pg.206]

Fig. 2. Reaction scheme for the first penem synthesis where V = CgH OCH2CONH. Fig. 2. Reaction scheme for the first penem synthesis where V = CgH OCH2CONH.
Fig. 3. Reaction scheme for the synthesis of the 6-(l-hydroxyethyl)-2-ethylthiopenem-3-carboxylates (92). Fig. 3. Reaction scheme for the synthesis of the 6-(l-hydroxyethyl)-2-ethylthiopenem-3-carboxylates (92).
Iminoboianes have been suggested as intermediates in the formation of compounds derived from the pyrolysis of azidoboranes (77). The intermediate is presumed to be a boryl-substituted nitrene, RR BN, which then rearranges to the amino iminoborane, neither of which has been isolated (78). Another approach to the synthesis of amino iminoboranes involves the dehydrohalogenation of mono- and bis(amino)halobotanes as shown in equation 21. Bulky alkah-metal amides, MNR, have been utilized successfully as the strong base,, in such a reaction scheme. Use of hthium-/i /f-butyl(ttimethylsilyl)amide yields an amine, DH, which is relatively volatile (76,79). [Pg.264]

Oxidation of thiophene with peracid under carefully controlled conditions gives a mixture of thiophene sulfoxide and 2-hydroxythiophene sulfoxide. These compounds are trapped by addition to benzoquinone to give ultimately naphthoquinone (225) and its 5-hydroxy derivative (226) (76ACS(B)353). The further oxidation of the sulfoxide yields the sulfone, which may function as a diene or dienophile in the Diels-Alder reaction (Scheme 88). An azulene synthesis involves the addition of 6-(A,A-dimethylamino)fulvene (227) to a thiophene sulfone (77TL639, 77JA4199). [Pg.84]

Scheme 1 General reaction schemes tor the synthesis of five-membered heterocycles containing two or more heteroatoms by aldol-related reactions... Scheme 1 General reaction schemes tor the synthesis of five-membered heterocycles containing two or more heteroatoms by aldol-related reactions...
Numerous examples of N—S bond formation using oxidative conditions have been described in the literature. A convenient synthesis of isothiazoles involves the direct oxidation of -y-iminothiols and numerous variations have been studied (see Chapter 4.17), The oxidation of the amidine (248) to give the 3-aminoisothiazole (249) illustrates the reaction scheme (65AHC(4)107, 72AHC(14)1), which has been extended to the synthetically useful 5-amino-4-cyano-3-methylisothiazole (251) obtained by oxidation of (250) with hydrogen peroxide (75JHC883). [Pg.135]

Fornari, T., Rotstein, E., and Stephanopoulos, G. (1989). Studies on the Synthesis of Chemical Reaction Paths — II. Reaction Schemes with Two Degrees of Freedom, Chem. Eng. Sc/, 44(7), 1569-1579. [Pg.295]

For the construction of oxygen-functionalized Diels-Alder products, Narasaka and coworkers employed the 3-borylpropenoic acid derivative in place of 3-(3-acet-oxypropenoyl)oxazolidinone, which is a poor dienophile in the chiral titanium-catalyzed reaction (Scheme 1.55, Table 1.24). 3-(3-Borylpropenoyl)oxazolidinones react smoothly with acyclic dienes to give the cycloadducts in high optical purity [43]. The boryl group was converted to an hydroxyl group stereospecifically by oxidation, and the alcohol obtained was used as the key intermediate in a total synthesis of (-i-)-paniculide A [44] (Scheme 1.56). [Pg.36]

As a demonstration of the complete synthesis of a pharmaceutical in an ionic liquid, Pravadoline was selected, as the synthesis combines a Friedel-Crafts reaction and a nucleophilic displacement reaction (Scheme 5.1-24) [53]. The allcylation of 2-methylindole with l-(N-morpholino)-2-chloroethane occurs readily in [BMIM][PF6] and [BMMIM][PF6] (BMMIM = l-butyl-2,3-dimethylimida2olium), in 95-99 % yields, with potassium hydroxide as the base. The Friedel-Crafts acylation step in [BMIM][PF6] at 150 °C occurs in 95 % yield and requires no catalyst. [Pg.186]

Problem 16.24 In planning a synthesis, it s as important to know what not to do as to know what to do. As whiten, the following reaction schemes have flaws in them. What is wrong with each ... [Pg.585]

Figure 16-7. Reaction scheme for the synthesis of ocl-OPV5 (R=n-oclyl) and Ooct-OPV5 (R=il-oclyloxy). Figure 16-7. Reaction scheme for the synthesis of ocl-OPV5 (R=n-oclyl) and Ooct-OPV5 (R=il-oclyloxy).
Figure 16-8. Reaction. scheme for the synthesis of Oocl-OPV5-CN (R= i-oelyloxy). Figure 16-8. Reaction. scheme for the synthesis of Oocl-OPV5-CN (R= i-oelyloxy).
As in the synthesis of (+)-26 (Scheme 8), treatment of (-)-27 with chromic acid accomplishes oxidative scission of the carbon-carbon double bond, and provides (-)-26 after an intramolecular bislactonization reaction (Scheme 16). By analogy to the conversion of 50 into 51 (see Scheme 8), treatment of (-)-26 with ammo-... [Pg.124]

The reaction scheme for RAFT copolymerization is relatively complex (Scheme 9.49) when considered alongside that for NMP or ATRP (Scheme 9.48). A summary of RAF T copolymerizations is provided in fable 9.22. An advantage of RAFT over other methods is its greater compatibility with monomers containing protic functionality though as yet few have taken advantage of this in the synthesis of functional copolymers. [Pg.529]

Poly(tetramethylene oxide) polyols (see Scheme 4.4) are a special class of polyethers syndiesized via acid-catalyzed ring-opening polymerization of tetrahy-drofuran. Although less susceptible to side reactions, the synthesis of these C4 ethers is less flexible in terms of product composition and structure. Thus, because of diis syndietic route, only two-functional glycols are available and copolymers are not readily available. Molecular weights of commercial C4 glycols range up to about 3000 g/m. [Pg.223]

During the synthesis of functional disiloxanes via hydrosilation, the starting materials are usually either tetramethyldisiloxane or dimethylchlorosilane and a proper olefinic (mostly allyl type) compound having the desired functional end group. If dimethylchlorosilane is employed, the hydrosilation is usually followed by hydrolysis. As a specific example, the synt hesis of 1,3-bis(3-glycidoxypropyl)tetramethyldisiloxane is shown in Reaction Scheme IV. [Pg.14]

Surprisingly, after this very first example, there was a 20 year delay in the literature in the appearance of the second report on siloxane macromonomers. However, during this period there have been numerous studies and developments in the vinyl and diene based macromonomers91 -94). The recent approach to the synthesis of siloxane macromonomers involves the lithiumtrimethylsilanolate initiated anionic polymerization of hexamethyltrisiloxane in THF 95,123). The living chain ends were then terminated by using styrene or methacrylate functional chlorosilanes as shown in Reaction Scheme X. [Pg.23]


See other pages where Reaction schemes synthesis is mentioned: [Pg.576]    [Pg.728]    [Pg.85]    [Pg.466]    [Pg.140]    [Pg.156]    [Pg.254]    [Pg.297]    [Pg.755]    [Pg.135]    [Pg.262]    [Pg.542]    [Pg.399]    [Pg.68]    [Pg.71]    [Pg.16]    [Pg.19]    [Pg.33]   


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