Non-covalent synthesis

Supramolecular, non-covalent, synthesis consists in the generation of supramolecular architectures through the designed assembly of molecular components directed by the physico-chemical features of intermolecular forces like molecular, covalent, synthesis, it requires strategy, planning and control. 

The first approach (Fig. 4A) called diastereoselective non-covalent synthesis regards the self-assembly of chiral units which bear stereogenic centers or which are intrinsically chiral (for instance because of atropoiso-... 

Fig. 7 Schematic representation of highly diastereoselective non-covalent synthesis A (RJt) chiral dimelamine and achiral barbiturate components lead only to the (M) double rosettes with very high d.e. B Achiral hindered dimelamine and chiral barbiturate leads to highly solvent dependent asymmetric induction, while C achiral alkyl dimelamine and chiral barbiturate components lead instead to all the isomeric double rosettes with different symmetry...

Fig. 8 Schematic representation of highly diastereoselective non-covalent synthesis achiral dimelamine calix[4]arene with enantiopure chiral cyanurate components lead to chiral double rosettes with d.e. as high as 96% (R)-cyanurate induces complete (P) chirality, while (S) favors only (M) chirality...

Fig. 24 Enantioselective non covalent synthesis of double rosettes exploiting the chiral memory effect. Exchange of chiral barbiturate with the achiral cyanurate occurs faster then racemization by dissociation of the supramolecular structure and allows temporary preservation of the asymmetry instructed in the first diastereoselective step...

The non-covalent synthesis of discrete macrocyclic and macrooligocyclic structures using multiple hydrogen-bonding interactions has now become a reality. The supramolecular approach outlined here represents an attractive and effective alternative to traditional stepwise covalent synthesis. Use of multiple hydrogen bonds to organize molecular components into supramolecular nanostructures has... 

The non-covalent synthesis of the chiral porphyrin aggregate has been performed as discussed in the previous paragraph. Addition of an equimolar amount of H6TPyP4+ and CuTPPS (Figs. 14 and 1, respectively) to a solution at pH 2.3 (by HC1) of L-Phe or D-Phe leads to mirror images induced CD signal in the... 

Co-crystals Solid-state Targets for Non-covalent Synthesis... 

Fig. n.i. Reaction scheme of the formation of supermolecules via non-covalent synthesis. 

---