Marine soft corals

Covalent synthesis of complex molecules involves the reactive assembly of many atoms into subunits with aid of reagents and estabUshed as well as innovative reaction pathways. These subunits are then subjected to various reactions that will assemble the target molecule. These reaction schemes involve the protection of certain sensitive parts of the molecule while other parts are being reacted. Very complex molecules can be synthesized in this manner. A prime example of the success of this approach is the total synthesis of palytoxin, a poisonous substance found in marine soft corals (35). Other complex molecules synthesized by sequential addition of atoms and blocks of atoms include vitamin potentially anticancer KH-1 adenocarcinoma antigen,... 

Abstract Recent chemical studies on the marine soft corals and terrestrial plants have lesnlted in the isolation of several novel componnds. The soft corals, Pseudopterogorgia elisabethae and Cladiella species yielded several novel terpenoids, exhibiting antimicrobial activities. New steroids were isolated from terrestrial fungi, Mucor plumbeus and Coprims micaceus. Phytochemical studies on the Buxus hyrcana, collected from Iran, have yielded steroidal bases. This revdew describes the new natiual products exhibiting different bioactivities from the aforementioned sources. 

Bioactive Sesquiterpenoids from the Marine Soft Coral of Genus Cladiella... 

Matthie. G.F. Konig, G.M. Wright, A.D. (1998) Three new diterpenes from the marine soft coral Lobophytum crassum. J. Nat. Prod., 61, 237-40. 

Lievens SC, Hope H, Molinski TF (2004) New 3-Oxo-chol-en-24-oic Acids from the Marine Soft Coral Eleutherobia sp. J Nat Prod 67 2130... 

The natural product eleutherobin (1) was isolated in 1994 by Fenical et al. from a marine soft coral from an Eleutherobia species and its structure was elucidated shortly afterwards (Figure 1) [1]. Eleutherobin is a diterpene glycoside that possesses remarkable cytotoxicity against a wide variety of cancer cells, which is likely to be based on binding to tubulin and stabilization of microtubules [2, 3]. Mitosis is interrupted and the cell division cycle is terminated. The mechanism of action of eleutherobin is comparable to that of highly potent cytostatic agents such as paclitaxel (Taxol), nonataxel, epothilones, and discodermolide. 

Di51 Sarcophytol A Marine soft coral EBV, Colon-2, Liver-2, Lung-1, Mam-3, Pancr, [97-100,204,205]... 

Di 143 6-Deacetoxy-14,15-deepoxy-xeniculin Marine soft coral AOS [224]... 

Enantioselective reduction of an a, -enone. One of the final steps in a synthesis of palytoxin, a toxin of marine soft corals containing 115 carbon atoms and 60 chiral centers, involves, in addition to the usual deprotections, enantioselective reduction of an enone to an allylic alcohol. A mixture (1 1) is obtained with borohydrides, but lithium borohydride combined with EuC13 provides an 8 1 mixture, with the desired isomer being favored. 

Overman et al. were the first to synthesize the eunicellane carbon skeleton [20]. In contrast to eleutherobin (1), (-)-7-deacetoxyalcyonin acetate (45) from the marine soft coral Cladiella sp. [21] shows the oxygen bridge between C2 and C9 instead of C4 and C7. Starting from 5(+)-carvone, an elegant Prins-pinacol conden-... 

Naturally occurring cembranoid epoxides (cembranoxides) (Figure 6-10) have been found as chemical components of various tropical marine soft corals and represent a... 

Let s complete this discussion with palytoxin (C129H223N3O54), a complex organic molecule first isolated from marine soft corals of the genus Palythoa (Figure 1), and one of the most potent poisons known. 

Palytoxin, a toxic component isolated from marine soft corals of the genus Pafythoa... 

Paly toxin Marine soft coral Biotoxin ... 

The anti-mitotic diterpene Eleutherobin (35) and Sarcodictyins A - D (36a-d) are structurally related, natural compounds isolated from the marine soft coral Eleutherobia spec, and Sarcodictyon roseum,... 

BIOACTIVE METABOLITES FROM SOUTHERN AFRICAN MARINE SOFT CORALS (PHYLUM COELENTERATA)... 

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