Rashes derivatives

QHgNiOiS. Colourless crystals, m.p. 164 5-166-5" C. It is usually prepared by treating p-acetamidobenzenesulphonyl chloride with ammonia, and hydrolysing the acetyl derivative to the base. Used for the treatment of streptococcal infections, gonorrhoea, meningococcal meningitis and urinary infections. Liable to cause unpleasant reactions, such as nausea, cyanosis and skin rashes. 

Since many of the uses of antihistamines involve conditions such as rashes, which should be treatable by local application, there is some rationale for developing drugs for topical use. The known side effects of antihistamines could in principle be avoided if the drug were functionalized so as to avoid systemic absorption. The known poor absorption of quaternary salts make such derivatives attractive for nonabsorbable antihistamines for topical use. Thus, reaction of the well-known anti his-taminic drug promethazine (104) with methyl chloride leads... 

DNA viruses Poxviruses Variola Vaccinia Large particles 200 x 250nm complex symmetry Variola is the smallpox virus. It produces a systemic infection with a characteristic vesicular rash affecting the face, arms and legs, and has a high mortality rate. Vaccinia has been derived from the cowpox virus and is used to immunize against smallpox... 

Jones TD, Walsh PJ, Zeighami EA. 1985. Permissible concentrations of chemicals in air and water derived from RTECS entries A "rash" chemical scoring system. Toxicol Ind Health 1 213-234. 

Hypersensitivity to tacrine or acridine derivatives patients previously treated with tacrine who developed treatment-associated jaundice a serum bilirubin greater than 3 mg/dL signs or symptoms of hypersensitivity (eg, rash or fever) in association with ALT elevations. 

Efavirenz (Sustiva) [Antiretroviral/NNRTI] Uses Hiv infxns Action Antiretroviral nonnucleoside RTI Dose Adults. 600 mg/d PO qhs Feds. See package insert avoid high-fat meals Caution [D, ] CDC recommends HIV-infected mothers not breast-feed Contra Component sensitivity Disp Caps SE Somnolence, vivid dreams, dizziness, rash, N/V/D Interactions T Effects W/ ritonavir T effects OF CNS depressants, ergot derivatives, midazolam, ritonavir, simvastatin, triazolam, warfarin X effects W/ carbamazepine, phenobarbital, rifabutin, rifampin, saquinavir, St. John s wort i effects OF amprenavir, carbamazepine, clarithromycin, indinavir, phenobarbital, saquinavir, warfarin may alter effectiveness OF OCPs EMS Concurrent EtOH usage can t CNS d ression OD May cause muscle contractions and adverse CNS effects activated charcoal may be effective... 

Alemtuzumab is a recombinant DNA-derived humanized monoclonal antibody used in the treatment of chronic lymphocytic leukemia and T-cell lymphoma. It targets CD52, a protein present on the surface of mature lymphocytes. Alemtuzumab has been associated with infusion-related events including hypotension, rigors, fever, shortness of breath, bron-chospasm, chills, and/or rash. Also reported were syncope, pulmonary infiltrates, cardiac arrhythmias, myocardial infarction and cardiac arrest. 

N.A. Balsaminones, 2-methoxy-l, 4-naphthoquinone, saponins, quercitin, kaempferol derivatives, balsaminasterol, parinaric acid, hosenkosides.302 Remedy for rashes, pain caused by insect bites, anti-inflammation. 

The newer derivatives seem less likely to cause hypersensitivity reactions, perhaps because the protein adducts generated are shorter lived. All four types of hypersensitivity reaction have been observed with penicillin. Thus, high doses may cause hemolytic anemia and immune complex disease and cell-mediated immunity may give rise to skin rashes and eruptions, and the most common reactions are urticaria, skin eruptions, and arthralgia. Antipenicillin IgE antibodies have been detected consistently with an anaphylactic reaction. The anaphylactic reactions (type 1 see above), which occur in 0.004% to 0.015% of patients, may be life threatening. 

Echinacea is derived from the root and seeds of the Echinacea plant that grows in parts of the Midwestern United States. This herb is used primarily to stimulate or support the immune system, and is often used to treat cold symptoms and other relatively minor respiratory tract infections.8 38 Although the exact reasons for beneficial effects are unclear, there is considerable evidence that echinacea preparations can reduce symptoms of the common cold when taken soon after symptoms appear.5,71 The ability of echinacea to prevent colds and other infections, however, is less well defined.49 Echinacea can also be administered topically to treat burns and other localized wounds. The most common side effects associated with echinacea are gastrointestinal (GI) upset, skin rash, and other allergic or hypersensitivity reactions.36... 

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