Randomized trial internal groups

Failure of extracranial-intracranial arterial bypass to reduce the risk of ischemic stroke. Results of an international randomized trial. The EC/IC Bypass Study Group. N Engl J Med 1985 313 1191-1200. 

ISIS-2 (Second International Study of Infarct Survival) Collaborative Group. Randomized trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction ISIS-2. Lancet 1988 2 349-360. 

Altman DG, Schultz KF, Moher D, Egger M et al. for the CONSORT Group (2001) The revised CONSORT statement for reporting randomized trials explanation and elaboration Annals of Internal Medicine, 134, 663-694... 

MUler DH, Khan OA, Sheremata WA, Blumhardt LD et al., for the International Natalizumab Multiple Sclerosis Trial Group (2003) A controUed trial of natalizumab for relapsing multiple sclerosis New England Journal of Medicine, 348, 15-23 Moher D, Schulz KF and Altman DG (2001) The CONSORT statement Revised recommendations for improving the quahty of reports of paraUel-group randomized trials Annals of Internal Medicine, 134, 657-694... 

McCloskey, R.V., Straube, R.C., Sanders, C., Smith, S.M., Smith, C.R. Treatment of septic shock with human monoclonal antibody HA-1A. A randomized, double-blind, placebo-controlled trial. CHESS Trial Study Group. Ann Intern Med 121 (1994) 1-5. 

Conant MA, Schacker TW, Murphy RL, Gold J, Crutchfield LT, Crooks RJ, Acebes LO, Aiuti F, Akil B, Anderson J, Melville RL, Ballesteros Martin J, Berry A, Weiner M, Black F, Anderson PL, Bockman W, Borelli S, Bradbeer CS, Braffman M, Brandon W, Clark R, Wisniewski T, Bruun JN, Burdge D, Caputo RM, Chateauvert M, LaLonde R, Chiodo F, et al. International Valaciclovir HSV Study Group. Valaciclovir versus aciclovir for Herpes simplex virus infection in HIV-infected individuals two randomized trials. Int J STD AIDS 2002 13(1) 12-21. 

Wils JA, Bliss JM, Marty M, Coombes G, Fontaine C, Morvan F, Olmos T, Perez-Lopez FR, Vassilopoulos P, Woods E, Coombes RC. Epirubicin plus tamoxifen versus tamoxifen alone in node-positive postmenopausal patients with breast cancer a randomized trial of the International Collaborative Cancer Group. J Clin Oncol 1999 17(7) 1988-98. 

The IPPPSH Collaborative Group. Cardiovascular risk and risk factors in a randomized trial of treatment based on the beta-blocker oxprenolol the International Prospective Primary Prevention Study in Hypertension (IPPPSH). J Hypertens I985 3(4) 379-92. 

International Stroke Trial Collaborative Group. The International Stroke Trial (1ST) A randomized trial of aspirin, subcutaneous heparin, bodi, or neidier among 19,435 patients with acute ischemic stroke. Lancet 1997 349 1560-1581. 

Pols HA, Felsenberg D, Hanley DA, et al. Multinational, placebo-controlled, randomized trial of the effects of alendronate on bone density and fracture risk in postmenopausal women with low bone mass Results of the FOSIT study. Fosamax International Trial Study Group. Osteoporos Int 1999 9 461-468. 

International Collaborative Ovarian Neoplasm Group. Paclitaxel plus carboplatin versus standard chemotherapy with either single-agent carboplatin or cyclophosphamide, doxorubicin and cisplatin in women with ovarian cancer the ICON3 randomized trial. Lancet 2002 360 505-515. 

Camporese G, Bemardi E, Prandoni P, Noventa F, Verlato F, KANT (Knee Arthroscopy Nadroparin Thromboprophylaxis) Study Group et al (2008) Low-molecular-weight heparin versus compression stockings for thromboprophylaxis after knee arthroscopy a randomized trial. Ann Intern Med 149(2) 73-82... 

Different epidemiological studies suggest that raised plasma concentrations of total Hey may be a common, causal and treatable risk factor for athero-thromboembolic ischemic stroke. Therefore, a study aimed to assess the effect of Vitamins to Prevent Stroke (VITATOPS)—an international, multi-centre, randomized, double-blind, placebo-controlled clinical trial using a multivitamin therapy (folic acid 2 mg, vitamin Bg 25 mg, vitamin B12 500 pg) has been carried out. A total of 8000 patients were randomized and followed up for a mean period of 2.5 years (range 1-8 years) (VITATOPS Trial Study Group 2002). 

Malmstrom K, Rodriguez-Gomez G, Guerra J et al. Oral montelukast, inhaled beclomethasone, and placebo for chronic asthma. A randomized, controlled trial. Montelukast/Beclometha-sone Study Group. Ann Intern Med 1999 130 487-495. 

CAPRIE was a 19,185-patient, 304-center, international, randomized, double-blind, parallel-group trial comparing Plavix (75mg daily) with aspirin (325mg daily). The outcome was to compare the first occurrence of new ischemic stroke, new myocardial infarction, or other vascular death. The following are tabulated results ... 

Cushman WC, Reda DJ, Perry HM, Williams D, Abdellatif M, Materson BJ. Regional and racial differences in response to antihypertensive medication use in a randomized controlled trial of men with hypertension in the United States. Department of Veterans Affairs Cooperative Study Group on Antihypertensive Agents. Arch Intern Med 2000 160 825-831. 

Black S, Roman GC, Geldmacher DS, Salloway S, Hecker J, Burns A, Perdomo C, Kumar D, Pratt R Donepezil 307 Vascular Dementia Study Group. Efficacy and tolerability of donepezil in vascular dementia positive results of a 24-week, multicenter, international, randomized, placebo-con-trolled clinical trial. Stroke 2003 34(10) 2323-30. 

A multicenter, randomized, double-blind clinical trial showed no significant difference in duration of viral shedding, duration of pain, or time to loss of all symptoms in immimocompetent adults with an initial episode of genital HSV treated with oral valacyclovir or oral acyclovir (Valaciclovir International Study Group). 

Fife KH, et al. Valaciclovir versus acyclovir in the treatment of first-episode genital herpes infection. Results of an international, multicenter, double-blind, randomized clinical trial. The Valaciclovir International Herpes Simplex Virus Smdy Group. SexTransm Dis 1997 24(8) 481-486. 

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