Quadrupole time-of-flight mass

Q-ToF-LC-MS-MS quadrupole time-of-flight mass analyser in combination with (high performance) liquid chromatography and tandem mass spectrometry... 

Figure 3.10 Schematic of a quadrupole-time-of-flight mass spectrometer. From applications literature published by Micromass UK Ltd, Manchester, UK, and reproduced with permission.

Verhaert, P., Uttenweiler-Joseph, S., de Vries, M., Loboda, A., Ens, W., Standing, K.G. (2001). Matrix-assisted laser desorption/ionization quadrupole time-of-flight mass spectrometry an elegant tool for peptidomics. Proteomics 1, 118-131. 

Kuehn, A.V., Neubert, R.H.H. (2004). Characterization of mixtures of alkyl polyglycosides (plantacare). by liquid chromatography-electrospray ionization quadrupole time-of-flight mass spectrometry. Pharm. Res. 21(12), 2347-2353. 

The instrumental analysis for the identification of UV filters degradation products formed during the fungal treatment process was performed by means of HPLC coupled to tandem mass spectrometry using a hybrid quadrupole-time-of-flight mass spectrometer (HPLC-QqTOF-MS/MS). Chromatographic separation was achieved on a Hibar Purospher STAR HR R-18 ec. (50 mm x 2.0 mm, 5 pm, from Merck). In the optimized method, the mobile phase consisted of a mixture of HPLC grade water and acetonitrile, both with 0.15% formic acid. The injection volume was set to 10 pL and the mobile phase flow-rate to 0.3 mL/min. 

Y. Ma, Y. Lu, H. Zeng, D. Ron, W. Mo, T. A. Neubert, Characterization of phosphopeptides from protein digests using matrix assisted laser desorption/ionization time of flight mass spectra metry and nanoelectrospray quadrupole time of flight mass spectrometry, Rapid Commun. Mass Spectrom., 15, 1693 1700 (2001). 

With the introduction of the quadrupole time-of-flight mass spectrometers (Morris et al., 1996), it became possible to generate isotopically... 

Loboda A.V., Krutchinsky A.N., Bromisrski M., Ens W., and Standing K.G. (2000), A tandem quadrupole/time of flight mass spectrometer with a matrix-assisted laser desorption/ionization source design and performance, Rapid Commun. Mass Spectrom. 14, 1047-1057. 

Figeys, D., Lock, C., Taylor, L., and Aebersold, R. (1998). Microfabricated device coupled with an electrospray ionization quadrupole time-of-flight mass spectrometer protein identifications based on enhanced-resolution mass spectrometry and tandem mass spectrometry data. Rapid Commun. Mass Spectrom. 12, 1435 — 1444. 

Chernushevich, I. V. Loboda, A. V. Thomson, B. A. An introduction to quadrupole-time-of-flight mass spectrometry. J. Mass Spectrom. 2001, 36, 849-865. 

Hopfgartner, G. Vdbois, F. The impact of accurate mass measurements using quadrupole/time-of-flight mass spectrometry on the characterisation and screening of drug metabolites. Analusis 2000, 28, 906-914. 

J. H. Beattie, L Joncour, K. et al. Increasing throughput and information content for in vitro drug metabolism experiments using ultra-performance liquid chromatography coupled to a quadrupole time-of-flight mass spectrometer. Rapid Commun Mass Spectrom 2005, 19, 843-848. 

Yuan YZ, Liu X, Boyd JM, Qin F, Li J, Li XF (2009) Identiflcation of N-nitrosamines in treated drinking water using nanoelectrospray ionization high-fleld asymmetric waveform ion mobility spectrometry with quadrupole time-of-flight mass spectrometry. J Chromatogr Sci 47(l) 92-96... 

Magner J, Filipovic M, Alsberg T (2010) Application of a novel solid-phase-extraction sampler and ultra-performance liquid chromatography quadrupole-time-of-flight mass... 

March, R.E. et al., A fragmentation study of an isoflavone glycoside, genistein-7-O-glucoside, using electrospray quadrupole time-of-flight mass spectrometry at high mass resolution, Int. J. Mass Spectrom., 232, 171, 2004. 

Applications of Quadrupole Time-of-Flight Mass Spectrometry in Reactive Metabolite Screening... 

APPLICATIONS OF QUADRUPOLE TIME-OF-FLIGHT MASS SPECTROMETRY... 

Hop, C. E. C. A. (2004). Applications of quadrupole-time-of-flight mass spectrometry to facilitate metabolite identification. Am. Pharm. Rev. 7 76-79. 

Mortishire-Smith, R. J., O Connor, D., Castro-Perez, J. M., and Kirby, J. (2005). Accelerated throughput metabolic route screening in early drug discovery using high-resolution liquid chromatography/quadrupole time-of-flight mass spectrometry and automated data analysis. Rapid Commun. Mass Spectrom. 19 2659-2670. 

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