Pyridostigmine

Myasthenia gravis is a disease tiiat involves rapid fatigue of skeletal muscles because of die lack of ACh released at die nerve endings of parasympathetic nerve fibers. Drugs used to treat this disorder include ambeno-nium (Mytelase) and pyridostigmine (Mestinon). [Pg.222]

C5H5NO 109-00-2) see Distigmine bromide Pirbuterol Pyridostigmine bromide... [Pg.2400]

The answer is a. (Hardman, pp 161-169.) Although all of the listed compounds inhibit the activity of the cholinesterases, only edrophonium chloride is used in the diagnosis of myasthenia gravis. The drug has a more rapid onset of action (1 to 3 min following intravenous administration) and a shorter duration of action (approximately 5 to 10 min) than pyridostigmine... [Pg.189]

Recently, Noort et al developed a procedure that is based on straightforward isolation of adducted BuChE from plasma by means of affinity chromatography with a procainamide column, followed by pepsin digestion and LC/electrospray tandem MS analysis of a specific nonapeptide containing the phosphonylated active site serine-198 residue (5). This method surpasses the limitations of the fluoride-reactivation method, since it can also deal with dealkylated ( aged ) phosphonylated BuChE. The method allowed the positive analysis of several serum samples of Japanese victims of the terrorist attack in the Tokyo subway in 1995. Furthermore, the method could be applied for detection of ChE modifications induced by, e.g., diethyl paraoxon and pyridostigmine bromide, illustrating the broad scope of this approach. This new approach... [Pg.23]

A principle of the therapy for acute poisonings with OPC lies in the complex performance of cholinolytics (atropine, scopolamine, aprofene, amisile etc.) with reversible ChE inhibitors (pyridostigmine, proserine etc.) or cholinolytics with tranquillizers (diazepam, fenozepame etc)... [Pg.107]

Dimhuber P, French MC, Green DM, Leadbeater L, Stratton JA. The protection of primates against soman poisoning by pre-treatment with pyridostigmine. J. Pharm. Pharmacol. 31 295-299, 1979. [Pg.120]

Ray R, Clark III OE, Ford KW, Knight KR, Harris LW, Broomfield CA. A novel tertiary pyridostigmine derivative [3-(N,N-Dimethylcarbamyloxy)-l-methyl-A3-tetrahydropyridine] anticholinesterase properties and efficacy against soman. Fundam. Appl. Toxicol. 16 267-274, 1991. [Pg.122]

Peden-Adams, et al., Evaluation of immunotoxicity induced by single or concurrent exposure to N, JV-diethylm-toluamide, pyridostigmine bromide and JP-8 jet fuel, Toxicol. Ind. Health, 17, 192, 2001. [Pg.237]

Pyridostigmine About twelve years ago, the U. S. military provided pyridostigmone bromide as a pretreatment for nerve agent exposure. Each trooper received a blister pack... [Pg.266]

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