Pyridostigmine blood-brain barrier permeability

Simon. C. M Fitch, T. E Petty, E, and Haley, R, W. (2000). Stressful manipulations ihai elevate corticosterone reduce blood-brain barrier permeability lo pyridostigmine in the rat. Toxicol Appl Pharmacol 165, 99-105. 

The effectiveness of pyridostigmine pretreatment may not be conclusive evidence against the importance of central mechanisms in respiratory arrest it appears that there is at least partial permeability of the blood-brain barrier to polar compounds such as pyridostigmine, specifically in the regions of the fourth ventricle and brainstem, where respiratory centers are located. In addition, an increase in blood-brain barrier permeability occurs rapidly after soman administration.1314 The key observation... 

Abou-Donia, M.B., Khan, W.A., Suliman, H.B., and Abdel-Rehman, A.A. (2001). Sarin-induced increase in blood-brain barrier (BBB) permeability is augmented by coexposure with stress, pyridostigmine bromide (PB), DEET, and permethrin in rats. Conference on Illness Among Gulf War Veterans A Decade of Scientific Research, Alexandria, VA, January 24—26, 2001, p. 140. 

Amourette, C., Lamproglou, L, Barbier, L., et al., 2009. Gulf war illness effects of repeated stress and pyridostigmine treatment on blood-Tirain barrier permeability and cholinesterase activity in rat brain. Behav. Brain Res. 203,207-214. 

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