Pyridostigmine pretreatment

Von Bredow, J.D., Adams, N.L., Groff, W.A., Vick, J.A. (1991). Effectiveness of oral pyridostigmine pretreatment and cholinol dic-oxime therapy against soman intoxication in nonhuman primates. Fundam. Appl. Toxicol. 17 761-70. 

Walday, P., Aas, P., Haider, T., Fonnum, F. (1993). Effect of pyridostigmine pretreatment, HI-6 and toxogonin treatment on rat tracheal smooth muscle response to cholinergic stimulation after organophosphorus inhalation exposure. Arch. Toxicol. 67 212-19. 

Anderson, D.R., Harris, L.W., Woodard, C.L., Lennox, W.I. (1992). The effect of pyridostigmine pretreatment on oxime efficacy against intoxication by soman and VX in rats. Drug Chem. Toxicol. 15 285-94. 

Animal studies that have employed prophylactic protocols, for antidotes that would not be used as prophylaxes should be extrapolated to post-poisoning treatment cautiously. Likewise, those studies involving antidotes used on pyridostigmine-pretreated animals should be extrapolated to non-pretreated human populations with caution. 

Kluwe WM, Chinn JC, Feder P et al. (1987). Efficacy of pyridostigmine pretreatment against acute soman intoxication in a primate model. In Sixth Medical Chemical Defense Bioscience Review, pp. 227-234. Aberdeen Proving Ground, MD, USA US Army Medical Research Institute of Chemical Defense. 

Koplovitz I, Harris L, Anderson DR et al. (1992b). Reduction by pyridostigmine pretreatment of the efficacy of atropine and 2-PAM treatment of sarin and VX poisoning. Fund Appl Toxicol, 18, 102— 106. 

Worek, E. and Szinicz, L., Cardiorespiratory function in nerve agent poisoned and oxime + atropine treated guinea pigs Effect of pyridostigmine pretreatment, Arch. Toxicol, 69, 322, 1995. 

---