Pyridostigmine efficacy

Ray R, Clark III OE, Ford KW, Knight KR, Harris LW, Broomfield CA. A novel tertiary pyridostigmine derivative [3-(N,N-Dimethylcarbamyloxy)-l-methyl-A3-tetrahydropyridine] anticholinesterase properties and efficacy against soman. Fundam. Appl. Toxicol. 16 267-274, 1991. 

PROPAFENONE PARASYMPATHOMIMETICS 1 efficacy of neostigmine and pyridostigmine Uncertain propafenone has a degree of antinicotinic action that may oppose the action of parasympathomimetic therapy for myasthenia gravis Watch for poor response to these parasympathomimetics and t dose accordingly... 

Other carbamates also have a good prophylactic efficacy, especially physostigmine and aminostigmine (due to their central effect which is contrary to pyridostigmine) (Kim et al, 2002 Tuovinen and Haninen, 1999 Tonkopii, 2003). Experimental studies with transdermal administration of physostigmine suggest a serious interest in the prophylactic use of this drug (Tenner et al, 1995 Kim et al, 2005 Levy et al, 1992 Walter et al, 1995). 

Anderson, D.R., Harris, L.W., Woodard, C.L., Lennox, W.I. (1992). The effect of pyridostigmine pretreatment on oxime efficacy against intoxication by soman and VX in rats. Drug Chem. Toxicol. 15 285-94. 

Lipp, J. and Dola, T. Comparison of the efficacy of HS-6 versus HI-6 when combined with atropine, pyridostigmine and clonazepam for soman poisoning in the monkey. Arch. Int. Pharmacodyn. Ther., 246, 138, 1980. 

Lallement, G. et al.. Subchronic administration of pyridostigmine or huperzine to primates compared efficacy against soman toxicity. Drug Chem. Toxicol, 25, 309, 2002b. 

Kassa, J., and Vachek, J., A comparison of the efficacy of pyridostigmine alone and in the combination of pyridostigmine with anticholinergic drugs as pharmacological pretreatment of tabun-poisoned rats and mice, Toxicology, 177, 179-185,2002. 

Pyridostigmine pre-treatment increased the antidotal efficacy of oxime-atropine combinations in various studies, especially in soman-poisoned animals (Gordon et al, 1978 Dimhuber et al., 1979 Inns and Leadbeater, 1983 Leadbeater et al., 1985), but some reports indicate that pyridostigmine reduced the antidotal effect in sarin, VX and VR poisoning (Anderson et al, 1992 Koplovitz and Stewart, 1992 Maxwell et al, 1997). 

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