Pyridostigmine pre-treatment

Pyridostigmine pre-treatment increased the antidotal efficacy of oxime-atropine combinations in various studies, especially in soman-poisoned animals (Gordon et al, 1978 Dimhuber et al., 1979 Inns and Leadbeater, 1983 Leadbeater et al., 1985), but some reports indicate that pyridostigmine reduced the antidotal effect in sarin, VX and VR poisoning (Anderson et al, 1992 Koplovitz and Stewart, 1992 Maxwell et al, 1997). 

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