Nerve agent pretreatment pyridostigmine

To minimize such problems, continuous training is required so that soldiers are comfortable donning their protective equipment and operating in a chemically contaminated environment. Similarly, soldiers must understand the rationale for taking the nerve agent pretreatment, pyridostigmine, as an... 

Miosis, pain, dim vision, and nausea can be relieved by topical atropine in the eye. Pretreatment with carbamates may protect the cholinesterase enzymes before nerve agent exposure. Pyridostigmine bromide is available as a pretreatment for nerve agent exposure. It is available in 30 mg tablets tablets should be administered every 8h. When used prior to exposure, it should be followed by atropine and pralidoxime chloride after exposure. 

Keeler, J. R., Hurst, C. G., Dunn, M. A. (1991). Pyridostigmine used as a nerve agent pretreatment under war time conditions. Journal of the American Medical Association, 266, 693-695. 

Keeler JR, Hurst CG, Dunn MA Pyridostigmine used as a nerve agent pretreatment under wartime conditions. JAMA 266 693-695, 1991 Labbate LA, Snow MP Posttraumatic stress symptoms among soldiers exposed to combat in the Persian Gulf. Hospital and Community Psychiatry 43 831-833,... 

The inadequacy of postexposure therapy for nerve agent casualties, particularly those with potentially lethal exposures to soman, has been of great concern. Development of pyridostigmine, a peripherally active carbamate compound, as a nerve agent pretreatment adjunct has substantially improved the ability of the U.S. military to protect its soldiers from the lethal effects of nerve agents. A major deficiency of this pretreatment program—that it does not protect the CNS against... 

Pyridostigmine About twelve years ago, the U. S. military provided pyridostigmone bromide as a pretreatment for nerve agent exposure. Each trooper received a blister pack... 

Pyridostigmine About twelve years ago, the U.S. military provided pyridostigmone bromide as a pretreatment for nerve agent exposure. Each trooper received a blister pack containing twenty-one 30-mg tablets for a dose regimen of one 30-mg tablet every eight hours. When given before soman exposure and when that exposure is followed by the standard MARK I therapy, the use of this pretreatment will increase the LD-50 several fold over the LD-50 obtained without the use of the pretreatment. When soman is the nerve... 

Pyridostigmine bromide studies have been performed in dogs, guinea pigs, monkeys, rabbits, rats, and mice. Diarrhea, salivation, tremors, and respiratory failure were seen prior to death. Side effects of the drug are related to muscarinic and nicotinic effects. Toxicity is also related to cholinergic stimulation. Effectiveness of pretreatment to reduce lethality after exposure to nerve agents (in particular, soman) is dependent on the administration of atropine and pralidoxime, postexposure. 

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