Pyridostigmine bromide

Chemical Name 3-[[(Dimethylamino)carbonyl]oxy]-1-methylpyridinium bromide Common Name — 

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C5H5NO 109-00-2) see Distigmine bromide Pirbuterol Pyridostigmine bromide... 

Recently, Noort et al developed a procedure that is based on straightforward isolation of adducted BuChE from plasma by means of affinity chromatography with a procainamide column, followed by pepsin digestion and LC/electrospray tandem MS analysis of a specific nonapeptide containing the phosphonylated active site serine-198 residue (5). This method surpasses the limitations of the fluoride-reactivation method, since it can also deal with dealkylated ( aged ) phosphonylated BuChE. The method allowed the positive analysis of several serum samples of Japanese victims of the terrorist attack in the Tokyo subway in 1995. Furthermore, the method could be applied for detection of ChE modifications induced by, e.g., diethyl paraoxon and pyridostigmine bromide, illustrating the broad scope of this approach. This new approach... 

Peden-Adams, et al., Evaluation of immunotoxicity induced by single or concurrent exposure to N, JV-diethylm-toluamide, pyridostigmine bromide and JP-8 jet fuel, Toxicol. Ind. Health, 17, 192, 2001. 

Pyridostigmine Bromide An antidote enhancer that blocks acetylcholinesterase, protecting it from nerve agents. When taken in advance of nerve agent exposure, pyridostigmine bromide increases survival provided that atropine and oxime and other measures are taken. 

Benzyl penicillin 5-Fluorouracil Acebutolol Sulphadiazine Isoprenaline Prednisolone Guanethidine Pyridostigmine bromide Additional problems... 

Cholinestrase inhibitors neostigmine bromide pyridostigmine bromide... 

Cook, M.R., Graham, Ch., Sastre, A., Gerkovich, M.M. Physiological and performance effects of pyridostigmine bromide in healthy volunteers a dose-response study. Psychopharmacology 162, 186-192, 2002. 

However, severe constraints do exist on DoD use of IND drugs and vaccines for CBW defense in military combat. The issue of IND use arose in the Gulf War in the case of pyridostigmine bromide (PB), which was regarded as the most effective pretreatment against exposure to the nerve gas Soman, and pentavalent botulinum toxoid (BT)... 

U.S. Food and Drug Administration, FDA Approves Pyridostigmine Bromide as a Pretreatment Against Nerve Gas, press release FDA News), February 5, 2003a, available at www.fda.gov/bbs/topics/ NEWS/2003/NEW00870.html (accessed August 2003). 

Exposure of soldiers to Pyridostigmine Bromide (PB), a toxic yellow liquid commonly used as a solvent in paints and medicines, NAPS tablets and vaccinations both in large numbers and in various types have now been recognised and acknowledged by both the British and the American governments. Additionally, in the theatre of operations,... 

Notes X = A known adverse effect by an agent CNS = Central nervous system ANS = Autonomic nervous system CV = Cardiovascular system PB = Pyridostigmine bromide OP = Organophosphates CB = Carbamates Pyreth = Pyrethroids Lind = Lindane NA = Nerve agents Mus = Mustard agents Du = Depleted uranium. 

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