2- Pyridinethiol-l-oxide

N-Hydroxythiopyridone is purchased from the Olin Corp. as an aqueous 40% solution of sodium 2-pyridinethiol-l-oxide (sodium omadine). Sodium omadine (1 L) is diluted with water (H2O, 600 mL) and the solution cooled to 0°C. Hydrochloric acid (350 mL) is added dropwise over a 20-min interval with continuous stirring and cooling for a further 20 min. The resulting suspension containing N-hydroxythio-pyridone is filtered and the solid is washed with H2O (2 L). The N-hydroxythiopyridone is dried over sodium hydroxide or potassium hydroxide under reduced pressure and... 

A number of zinc compounds with organic constituents (e.g., zinc salts of organic acids) have therapeutic uses. These include antidandruff zinc pyridinethione, antifungal zinc undecylenate used to treat athlete s foot, zinc stearate and palmitate (zinc soap), and antibacterial zinc bacitracin. Zinc naphthenate is used as a low-toxicity wood preservative, and zinc phenolsulfonate has insecticidal properties and was once used as an intestinal antiseptic. The inhalation of zinc soaps by infants has been known to cause acute fatal pneumonitis characterized by lung lesions similar to, but more serious than, those caused by talc. Zinc pyridine thione (zinc 2-pyridinethiol-l-oxide) has been shown to cause retinal detachment and blindness in dogs this is an apparently species-specific effect because laboratory tests at the same and even much higher dosages in monkeys and rodents do not show the same effect. 

SYNS BIS(l-HYDROXY-2(lH)-PYR]DINETHIONATO)-ZINC BIS(2-PYRIDYLTHIO)ZINC, l,l -DIOXIDE OM-1563 ONIADINEZINC 2-PYRIDINETHIOL-l-OXIDE, ZINC S. LT PYRITHIONE ZINC VANCIDE P ZINC OXLYDINE ZINCPOLYANEMINE ZINC PT ZINC PYRIDINETHIONE ZINC PYIUON ... 

PYRIDINETHIOL-l-OXIDE, ZINC SALT see ZMJOOO PYRIDINE, 4-VALERYL- see A100... 

Zinc pyrithione, or zinc bis-(2-pyridinethiol-l-oxide) is a zinc derivative of 2-mercaptopyridine 1-oxide (in another nomenclature), or zinc omadine. It serves as an ingredient in Head Shoulders shampoo. For oral administration, its LD50 in rats equals to 92-266 mg/kg, in mice 160-1000 mg/kg, and in dogs 600 mg/kg. 

Zero-shear viscosity, 631, 642, 648 Zig-zag stereoconfiguration, 57, 59 Zinc bis-(2-pyridinethiol-l-oxide), 452 Zinc borate, 432, 433,440, 470 Chemical formula, 470 Cost, 441... 

Sodium metaperiodate Periodic acid, sodium salt (7790-28-5), 75, 108 Sodium nitrite Nitrous acid, sodium salt (7632-00-0), 75, 37 Sodium omadine See Sodium 2-pyridinethiol-1-oxide, 75, 125 Sodium 2-pyridinethiol-l-oxide (sodium omadine), 75,125 Sodium sulfide, 76, 95... 

Of the hundreds of chemicals that are efiective as antimicrobials, only a few are used in plastics applications. The most common group of active ingredients consists of 10,16-oxybisphenoxy arsine (OBPA, tradenames Intercide, Akzo Chemical Vinyzene, Morton International), 2- -octyl-4-isothia-zolin-3-one (tradenames Micro-Check 11, Ferro Corporation Vinyzene IT, Morton International), N-trichloro-methylthio-4-cycIohexene-l,2-dicarboximide (Captan, tradenames Vancide 89, R.T. Vanderbilt Fungitrol C, Hiils America), and N-(trichloromethylthio) phthalimide (Flopet, trade name Fungitrol 11, Huls America). Other antimicrobial active ingredients include amine-neutralized phosphate and zinc 2-pyridinethiol-l-oxide. 

Types 2-n-octyl-isothiazolin-3 -one, 2,3,5,6-tetrachloro-4-(methylsulphonyl)pyridine, 4,5-dichloro-2-n-octylisothiazolin-3-one, 10,10-oxybisphenoxarsine, chlorthalonil, n-butyl-1,2-benzisothiazolin-3 -one, (N-dichlorofluoromethylthiophthalimide-(trichlorom-ethylthio)phthalimide, zinc bis(2-pyridinethiol-l-oxide)... 

Sodium benzoate Sodium pentachlorophenol Sodium 2-pyridinethiol-l-oxide Sodium sorbate Sodium dehydroacetate l,2-Dibenzisothiazolin-3-one... 

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