Pulmonary endothelium

Alber S., Huang L., Watkins S., Li S. Lipid-mediated delivery of peptide nucleic acids to pulmonary endothelium. 

Protection of vascular endothelial cells from oxygen free radical damages Enhancement of SOD, catalase and peroxidase in the cytosol of kidney Protection of pulmonary endothelium against free radicals in rabbits Protection of lipid peroxidation in liver and cardiac muscle in rats Inhibition of lipid peroxidation of rat liver and brain microsomes Inhibition of lipid peroxidation in serum and liver in rats Protective effect of ginsenosides on reperfusion injuries... 

Mechanism of the pulmonary vasodilation of the P. ginseng standardized extract G115 in rabbits release of NO from the pulmonary endothelium. 

Li, S., Tan, Y., Viroonchatapan, E., Pitt, B.R. and Huang, L. (2000) Targeted gene delivery to pulmonary endothelium by anti-PECAM antibody. Am. J. Physiol., 278, L504-L511. 

Pulmonary Endothelium in Health and Disease, edited by U. S. Ryan... 

Pulmonary gene therapy is attractive for the treatmment of chronic bronchitis, cystic fibrosis, a-1 antitrypsin deficiency, familial emphysema, asthma, pulmonary infections, surfactant deficiency, pulmonary hypertension, lung cancer, and malignant mesothelioma. The pulmonary endothelium may act as a bioreactor for the production and secretion of therapeutic proteins, such as clotting factors and erythropoietin into the blood circulation. There is a potential benefit for acquired lung diseases, as well as cancers, to be controlled and possibly treated by expression of cytokines, surfactant, antioxidant enzymes, or mucoproteins within lung cells. 

Like benzo[r ]pyrene, benz[a]anthracene may cross the gastrointestinal lining, pulmonary endothelium, or percutaneous barriers. Benz[a]anthracene is biotransformed to five dihydrodiols and a number of phenolic metabolites by P450 mixed-function oxidases. Detectable levels of benz[a]anthracene can be observed in most internal organs from minutes to hours after administration. Regardless of route of administration, once metabolized, hepatobiliary excretion and elimination through feces is the major route. 

Ryan JW. Assay of pulmonary endothelial surface enzymes in vivo. In Ryan US, ed. Pulmonary Endothelium in Health and Disease. New York Marcel Dekker,... 

Pietra GG, Fishman AP, Lanken PN, et al. Permeability of pulmonary endothelium to neutral and charged macromolecules. Ann N Y Acad Sci 1982 401 241-247. 

In addition to causing their pulmonary sequestration, C5a can Induce release of oxygen radicals from neutrophils (45). Further, both C3a and C5a stimulate mast cells to release histamine. These substances can cause injury to the pulmonary endothelium. Increased vascular permeability and smooth muscle contraction. Such processes have been assoeiated with the severe anaphylactoid reactions reported to occur on rare occasions with the clinical use of membrane devices (46). A connection between complement activation and such reactions has been suggested but not proven. In addition, the sequelae of complement activation may produce the hypoxemia observed during hemodialysis (4 ) and the pulmonary hypertension described in an animal model of extracorporeal circulation (48). 

Muzykantov V. and Danilov, S. (1995) Targeting of radiolabeled monoclonal antibody against ACE to the pulmonary endothelium, in Targeted Delivery of Imaging Agents (Torchilin, V., ed.), CRC, Boca Ration, FL, pp. 465 485. 

Moldobaeva A and Wagner EM (2005) Difference in proangiogenic potential of systemic and pulmonary endothelium Role of CXCR2. Am J Physiol Lung Cell Mol Physiol 288 L1117—1123... 

Mamyama K, et al. Characterization of in vivo immunoliposomes targeting to pulmonary endothelium, J Pharm Sd 1990, 74, 978-984. 

Birukova, A.A. et al. Polar head groups are important for barrier-protective effects of oxidized phospholipids on pulmonary endothelium. Am. J. Physiol Lung Cell Mol. Physiol 292 (2007) L924-L935. 

Increased margination of leukocytes in the circulation of the lung through adhesion to the pulmonary endothelium and formation of platelet microaggregates have been postulated as important components in the etiology of... 

In our initial studies we used inhaled nitric oxide as a probe to test the effect of cardiopulmonary bypass on pulmonary endothelial function. Cardiopulmonary bypass may result in damage to the pulmonary endothelium, and the degree of pulmonary hypertension is correlated with the extent of such damage. Acetylcholine-induced vasodilation is attenuated in a number of vascular diseases that impair endothelial function,and preconstricted pulmonary artery rings from explanted lungs of patients with... 

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