Pseudomonas aeruginosa antimicrobial resistance

Moskowitz, S., Ernst, R., Miller, S. PmrAB, a two-component regulatory system of Pseudomonas aeruginosa that modulates resistance to cationic antimicrobial peptides and addition of aminoarabinose to lipid A. J Bacteriol 186 (2004) 575-579. 

Macfarlane, E.L., Kwasnicka, A., Hancock, R.E. Role of Pseudomonas aeruginosa PhoP-phoQ in resistance to antimicrobial cationic peptides and aminoglycosides. Microbiology 146(Pt 10) (2000) 2543-2554. 

McPhee, J.B., Lewenza, S., Hancock, R.E. Cationic antimicrobial peptides activate a two-component regulatory system, PmrA-PmrB, that regulates resistance to polymyxin B and cationic antimicrobial peptides in Pseudomonas aeruginosa. Mol Microbiol 50 (2003) 205-217. 

Chakrabarty et al. (1989) selected several antihistamines for detection of antibacterial action [15]. According to them, promethazine was the most powerful and significant antimicrobial. The authors observed that in staphylococci, shigellae, and vibrios the MIC of promethazine varied between 100 and 200 xg/ml. Although one strain of Escherichia coli was sensitive at 50 xg/ml, the others were resistant. With respect to Pseudomonas aeruginosa, Proteus vulgaris, and Providencia spp., the MIC of promethazine was always >200 pg/ml (Table 7). 

Zhang, L Li, X.Z. and Poole, K. (2001) Fluoroquinolone susceptibilities of efflux-mediated multidrug-resistant Pseudomonas aeruginosa, Stenotrophomonas maltophilia and Burkholderia cepacia. The Journal of Antimicrobial Chemotherapy, 48 (4), 549-552. 

B.H., and Storey, D.G. (2001) Multidrug efflux pumps expression patterns and contribution to antibiotic resistance in Pseudomonas aeruginosa biofilms. Antimicrobial Agents and Chemotherapy, 45 (6), 1761-1770. 

Nakae, T., Nakajima, A., Ono, T., Saito, K., and Yoneyama, H. (1999) Resistance to beta-lactam antibiotics in Pseudomonas aeruginosa due to interplay between the MexAB-OprM efflux pump and beta-lactamase. Antimicrobial Agents and Chemotherapy, 43 (5), 1301-1303. 

Sorocea muriculata Miq. (roots) Diels-Alder-type adducts Sorocenol G (431) Sorocenol H (429). Used traditionally to treat inflammation and gastric ulcers. Antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coU, Pseudomonas aeruginosa, and Mycobacterium intracellulare. Antifungal activity. Ross et al., 2008[275]. 

S. aureus and S. pyogenes account for the majority of community-acquired SSTIs. Data from the most recent SENTRY Antimicrobial Surveillance Program showed S.aureus to also be the most common cause (45.9%) of nosocomial SSTIs. Also of note in this study was the 30% incidence of methicillin resistance among strains of S. aureus. Other common nosocomial pathogens included Pseudomonas aeruginosa (11%), enterococci (8%), and E. coli (7%). ... 

The antimicrobial properties of conductive functionalised-polyaniline (f-PANI) have been investigated by exploring their interaction with different bacteria. It was observed that low concentrations of PANI strongly inhibited the growth of wild-type Escherichia coli. Pseudomonas aeruginosa and Staphylococcus aureus as well as several antibiotic-resistant clinical pathogens [18]. 

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