Pseudomonas aeruginosa biofilm

Hoyle, B. D., L. J. Williams, and J. W. Costerton. 1993. Production of mucoid exopolysaccharide during development of Pseudomonas aeruginosa biofilms. Infection and Immunity 61 777-780. 

O Toole, G. A., and R. Kolter. 1998. Flagellar and twitching motility are necessary for Pseudomonas aeruginosa biofilm development. Molecular Microbiology 30 295-304. 

Fig. 1 Examples of biofilms. Left typical mold in households. Center typical biofouling on a ship hull, including algaes and barnacles. Right microbial Pseudomonas aeruginosa biofilm on a catheter...

Mah T-F, Pitts B, Pellock B et al. (2003) A genetic basis for Pseudomonas aeruginosa biofilm antibiotic resistance. Nature 426 306-310... 

Matsui H., Wagner V.E., Hill D.B., Schwab U.E., Rogers T.D., Buttom B., Taylor R.M., Superfine R., Rubinstein M., Iglewski R.H. and Boucher R.C. (2006) A physical linkage between cystic fibrosis airway surface dehydration and Pseudomonas aeruginosa biofilms. Proc Natl Acad Sci USA 103, 18131-18136... 

Pamp, S.J., Gjermansen, M., Johansen, H.K., Talker-Nielsen, T. Tolerance to the antimicrobial peptide colistin in Pseudomonas aeruginosa biofilms is linked to metabolically active cells, and depends on the pmr and mexAB-oprM genes. Mol Microbiol 68 (2008) 223-240. 

Junker, L.M. and Clardy, J. 2007. High-throughput screens for small-molecule inhibitors of Pseudomonas aeruginosa biofilm development. Antimicrob. Agents Chemother. 51, 3582-3590. 

B.H., and Storey, D.G. (2001) Multidrug efflux pumps expression patterns and contribution to antibiotic resistance in Pseudomonas aeruginosa biofilms. Antimicrobial Agents and Chemotherapy, 45 (6), 1761-1770. 

Lee, J.-U., and Beveridge, T. J. (2001). Interaction between iron and Pseudomonas aeruginosa biofilms attached to Sepharose surfaces. Chem. Geol. 180, 67-80. 

Interestingly, chromosomal DNA released from bacterial cells (extracellular DNA/eDNA) has been shown to support Pseudomonas aeruginosa biofilm development [43], DNAse I inhibited nascent biofilm formation, and when added to established but still young biofilms disintegrated them to some extent, whilst the effect on mature (>82 h) biofilms was not as marked. The findings indicate a role for eDNA in early P. aeruginosa biofilm development [43],... 

Ichimiya, T., Yamasaki, T., and Nasu, T. (1994). In vitro effects of antimicrobial agents on Pseudomonas aeruginosa biofilm formation. J. Antimicrob. Chemother. 34, 331-341. 

Blenkinsopp et al [1992] have shown that the efficacy of some biocides against Pseudomonas aeruginosa biofilms grown on stainless steel studs, is increased by the application of a low strength electric field. Biocide concentrations lower than those necessary to kill planktonic cells were bactericidal within 24 h when applied within the electric field. It is possible that this discovery could have implications for industrial biofilm control in the future. 

Elkins, J. G., Hassett, D. J., Stewart, P. S., Schweizer, H. P., and McDermott, T. R. (1999). Pseudomonas aeruginosa biofilm resistance to hydrogen peroxide Protective role of catalase. Appl. Environ. Microbiol. 65, 4594-4600. 

Leid, J. G., Willson, C. J., Shirtliff, M. E., Hassett, D. J., Parsek, M. R., and Jeffers, A. K. (2005). The exopolysaccharide alginate protects Pseudomonas aeruginosa biofilm bacteria from IFN-gamma mediated macrophage killing. J. Immunol. 175, 7512-7518. 

According to the Centers for Disease Control and Prevention (CDC), 60% of all human infections are caused by biofilms. To broaden the potential of antimiaobial peptoids, the Barron and Spormann groups investigated the potential of selected peptoids against Pseudomonas aeruginosa biofilms. Pseudomonas aeruginosa is known to cause 200 000 hospital-acquired infections annually in the United States alone. This opportunistic bacterium can cause a variety of infections such as wound and ear, bone, urinary tract, and... 

Table 3 The percent reduction in bacterial biomass and cell viability of Pseudomonas aeruginosa biofilms by antimicrobials at...

De Prijck, K., Nelis, H. and Coenye, T. 2007. Efficacy of silver-releasing rubber for the prevention of Pseudomonas aeruginosa biofilm formation in water. Biofouling J. Bioadhes. Biofilm Res. 23(6) 405-411. 

GILLIS R J, WHITE K G, CHOI K.-H, WAGNER V E, SCHWEIZER H P and IGLEWSKI B H (2005) Molecular basis of Azithroycin-resistant Pseudomonas aeruginosa biofilms. Anti-microb Agents Chemother, 49,3858-3867. 

Mulcahy H, Charron-Mazenod L, Lewenza S. Extracellular DNA chelates and induces antibiotic resistance in Pseudomonas aeruginosa biofilms. PLoS Pathog 2008 4 e1000213. http //dx.doi.org/ 371 /journal.ppat. 

Blanchard, A. P., Bird, M. R. and Wright, S. J. L., 1998. Peroxygen disinfection of Pseudomonas aeruginosa biofilms on stainless steel discs. Biofouling 13, 233-253. 

Chen, C. I., Griebe, T., Srinivasan, R. and Stewart, P., 1993b. Effects of various metal substrata on accumulation of Pseudomonas aeruginosa biofilms and the efficacy of monochloramine as a biocide. Biofouling 7, 241-251. 

Cochran, W. L., McFeters, G. A. and Stewart, P. S., 2000. Reduced susceptibility of thin Pseudomonas aeruginosa biofilms to hydrogen peroxide and monochloramine. Journal of Applied Microbiology 88, 22-30. 

Hentzer, M., Teitzel, G. M., Balzer, G. J., Heydorn, A., Molin, S., Givskov, M. and Parsek, M. R. 2001. Alginate overproduction affects Pseudomonas aeruginosa biofilm structure and function. Journal of Bacteriology 183, 5395-5401. 

Suci, P. A., Mittelman, M. W., Yu, F. P. and Geesey, G. G., 1994. Investigation of ciprofloxacin penetration into Pseudomonas aeruginosa biofilms. Antimicrobial Agents and Chemotherapy 38, 2125-2133. 

Wood, P., Caldwell, D. E., Evans, E., Jones, M., Korber, D. R., Wolfaardt, G. M., Wilson, M. and Gilbert, P., 1998. Surface-catalyzed disinfection of thick Pseudomonas aeruginosa biofilms. Journal of Applied Microbiology 84, 1092-1098. 

Grobe, K. J., Zahller, J. and Stewart, P. S., 2002. Role of dose concentration in biocide efficacy against Pseudomonas aeruginosa biofilms. J. Ind Microbiol Bioteclmol. 29, KL15. 

I., Vinogradov, A.M., Stewart, P.S., Ratner, B.D. et al. (2005) Ultrasonically controlled release of ciprofloxacin from self-assembled coatings on poly(2-hydroxyethyl methacrylate) hydrogels for Pseudomonas aeruginosa biofilm prevention. Aniirtdcrdh. Agents Chemother., 49, 4272—4279. 

Stewart PS, Drury WJ, Murga R (1993) Quantitative observations of heterogeneities in Pseudomonas aeruginosa biofilms. Appl Environ Microbiol... 

Huigens, R.W.llL, Richards, J.J., Parise, G Ballard, T.E., Zeng, W, Deora, R and Melander, C. (2007) Inhibition of Pseudomonas aeruginosa biofilm formation with bromoageliferin analogues. J. Am, Chem, Soc 129, 6966-6967. 

M. Pasmore, P. Todd, S. Smith, D. Baker, J. SUverstein, D. Coons, C.N. Bowman, Effects of ultrafiltration membrane surface properties on Pseudomonas aeruginosa biofilm initiation for the purpose of reducing biofouling, J Memb Sci, 194 (2001) 15-32. 

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