PmrA-PmrB

Gunn, J.S., Lim, K.B., Krueger, J., Kim, K., Guo, L., Hackett, M., Miller, S.I. PmrA-PmrB-regulated genes necessary for 4-aminoarabinose lipid A modification and polymyxin resistance. Mol Microbiol 27 (1998) 1171-1182. 

Gunn, J.S., Ryan, S.S., Van Velkinburgh, J.C., Ernst, R.K., Miller, S.I. Genetic and functional analysis of a PmrA-PmrB-regulated locus necessary for lipopolysaccharide modification, antimicrobial peptide resistance, and oral virulence of Salmonella enterica serovar typhimurium. Infect Immun 68 (2000) 6139-6146. 

Al-Khodor, S., Kalachikov, S., Morozova, I., Price, C., Abu Kwaik, Y. The PmrA/PmrB two-component system of Legionella pneumophila is a global regulator required for intracellular replication within macrophages and protozoa. Infect Immun 77 (2009) 374-386. 

Delgado, M., Mouslim, C., Groisman, E. The PmrA/PmrB and RcsC/YojN/RcsB systems control expression of the Salmonella O-antigen chain length determinant. Mol Microbiol 60 (2006) 39-50. 

Kato, A., Latifi, T., Groisman, E. Closing the loop the PmrA/PmrB two-component system negatively controls expression of its posttranscriptional activator PmrD. Proc Natl Acad Sci USA 100(2003)4706-4711. 

McPhee, J., Bains, M., Winsor, G., Lewenza, S., Kwasnicka, A., Brazas, M., Brinkman, F., Hancock, R. Contribution of the PhoP-PhoQ and PmrA-PmrB two-component regulatory systems to Mg2-t-induced gene regulation in Pseudomonas aeruginosa. J Bacteriol 188 (2006) 3995-4006. 

McPhee, J.B., Lewenza, S., Hancock, R.E. Cationic antimicrobial peptides activate a two-component regulatory system, PmrA-PmrB, that regulates resistance to polymyxin B and cationic antimicrobial peptides in Pseudomonas aeruginosa. Mol Microbiol 50 (2003) 205-217. 

A two-component regulatory system has been characterized that is involved in the resistance of P. aeruginosa in response to external magnesium concentrations (26). Similarly, the PmrA/PmrB two-component system of Salmonella enterica that mediates modifications in the lipopolysaccharide, resulting in resistance to polymyxins, has been characterized in more detail (27). The pqaB locus affected polymyxin B resistance in Salmonella typhi (28). 

---