Efflux pumps multidrug

Nikaido H (1996) Multidrug efflux pumps in Gram-negative bacteria. J Bacteriol 178 5853-5859. 

Chaudhary, P. M., and Roninson, 1. B. (1991) Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells. Cell. 66, 85-94. 

Cherigo L, Pereda-Miranda R, Fragoso-Serrano M, Jacobo-Herrera N, Kaatz GW, Gibbons S (2008) Inhibitors of Bacterial Multidrug Efflux Pumps from the Resin Glycosides of Ipomoea murucoides. J Nat Prod 71 1037... 

H Nikaido. Antibiotic resistance caused by gram-negative multidrug efflux pumps. Clin Infect Dis 27 Suppl 1 32 11, 1998. 

H. E. Jones, I. B. Holland, A. Jacq, T. Wall and A. K. Campbell (2003). Escherichia coli lacking the AcrAB multidrug efflux pump also lacks nonproteinaceous, PHB-polyphosphate Ca2+ channels in the membrane. Biochim. Biophys. Acta, 1612, 90-97. 

Multidrug efflux pumps are tripartite export machines. A complex formed by an inner-membrane transporter and a periplasmic adaptor protein contacts an outer-membrane channel tunnel. Interaction with the adaptor protein leads to an opening of the periplasmic entrance of channel tunnel prerequisite for a successful export. 

Figure 20.7 Multidrug efflux pump. Model of a channel tunnel-dependent export apparatus. Interaction with the adaptor protein opens the entrance of the channel tunnel, allowing export of proteins or drugs. In contrast to the channel tunnel, the structure of the adaptor protein is unknown.

Jr. Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump. Science 2003 300(5621) 976-980. 85. 

Enniatins inhibit Pdr5p, one of the major multidrug efflux pumps whose... 

Kaatz GW, Moudgal W, Seo SM, and Kristiansen JE (2003) Phenothiazines and thioxanthenes inhibit multidrug efflux pump activity in Staphylococcus aureus. Antimicrobial Agents and Chemotherapy 47 719-726. 

Crowley E, Callaghan R (2010) Multidrug efflux pumps drug binding - gates or cavity FEBS J 277 530-539... 

MDR transporters are usually encoded by housekeeping genes as normal constituents of bacterial chromosome and are present in the whole population of a given bacterial species. The basal level of expression of nonspecific multidrug efflux pumps in wild-type cells determines the basal level of antibiotic susceptibility. This innate resistance may still be low enough such that bacteria are susceptible to therapy with a given antibiotic. 

Grkovic, S., Brown, M.H., and Skurray, R,A, (2001) Transcriptional regulation of multidrug efflux pumps in bacteria. Seminars in Cell ej Developmental Biology, 12 (3), 225-237. 

Yu, E.W., McDermott, G., Zgurskaya, H.I., Nikaido, H., and Koshland, D.E., Jr. (2003) Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump. Science,... 

Elkins, C.A. and Nikaido, H. (2002) Substrate specificity of the RND-type multidrug efflux pumps AcrB and AcrD of Escherichia coli is determined predominantly by two large periplasmic loops. Journal of Bacteriology, 184 (23), 6490-6498. 

Middlemiss, J.K. and Poole, K. (2004) Differential impact of MexB mutations on substrate selectivity of the MexAB-OprM multidrug efflux pump of Pseudomonas aeruginosa. Journal of Bacteriology, 186 (5), 1258-1269. 

Elkins, C.A. and Mullis, LB. (2007) Substrate competition studies using whole-cell accumulation assays with the major tripartite multidrug efflux pumps of Escherichia coli. Antimicrobial Agents and Chemotherapy, 51 (3), 923-929. 

Elkins, C.A. and Nikaido. H. (2003) Chimeric analysis of AcrA function reveals the importance of its C-terminal domain in its interaction with the AcrB multidrug efflux pump. Journal of Bacteriologf, 185 (18), 5349-5356. 

B.H., and Storey, D.G. (2001) Multidrug efflux pumps expression patterns and contribution to antibiotic resistance in Pseudomonas aeruginosa biofilms. Antimicrobial Agents and Chemotherapy, 45 (6), 1761-1770. 

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