Antimicrobial cationic peptides

Kosol S, Zangger K (2010) Dynamics and orientation of a cationic antimicrobial peptide in two membrane-mimetic systems. J Struct Biol 170 172-179... 

Blazyk J, Wiegand R, Klein J, Hammer J, Epand RM, Epand RF, Maloy WL, Kari UP (2001) A novel linear amphipathic beta-sheet cationic antimicrobial peptide with enhanced selectivity for bacterial lipids. J Biol Chem 276 27899-27906... 

Hancock, R. E. W. and Diamond, G., The role of cationic antimicrobial peptides in innate host defense, Trends Microbiol., 8, 402, 2000. 

As many of the phenotypic changes induced following PhoPQ activation involve host defense peptide resistance characteristics, it is postulated that host defense peptides serve as an endogenous ligand for PhoQ Indeed, the exposure of S. typhimurium to sublethal concentrations of cationic antimicrobial peptides results in activation of the PhoPI regulon and host defense peptide resistance phenotypes. " Supporting... 

Straus SK, Hancock RE. (2006) Mode of action of the new antibiotic for Gram-positive pathogens daptomycin Comparison with cationic antimicrobial peptides and lipopeptides. Biochim BiophysActa 1758 1215-1223. 

Another kind of contact-active antimicrobial surface was achieved by tethering antimicrobial peptides to surfaces [62], If such peptides were exclusively membrane-active they could not work like in solution but would be immobilized via a polymeric spacer that could potentially cross the cell wall. The latter was demonstrated by the group of Dathe, who immobilized cationic antimicrobial peptides on PentaGels [63], Also, the well-known antimicrobial peptide magainin I... 

Bagheri M, Beyermann M, Dathe M (2009) Immobilization reduces the activity of surface-bound cationic antimicrobial peptides with no influence upon the activity spectrum. Antimicrob Agents Chemother 53 1132-1141... 

Pereira, H.A. (2006) Novel therapies based on cationic antimicrobial peptides. Curr. Pharm. Biotechnol. 7(4), 229-234. 

Short Linear Cationic Antimicrobial Peptides Screening, Optimizing, and Prediction... 

Despite the variety of different sources, sequences and structures, all cationic antimicrobial peptides share some common features small size (12-50 amino acids), positive net charge (+2 to +9), amphiphilic (>30% hydrophobic amino acids) and antimicrobial and/or immunomodulatory activity. Some cationic antimicrobial peptides also show antiviral (14) and/or anticancer activity (15) as well as wound healing properties (16). More than 1000... 

Hilpert, K. and Hancock, R.E.W. (2007) Use of luminescent bacteria for rapid screening and characterization of short cationic antimicrobial peptides synthesized on cellulose by peptide array technology. Nature Protocols, 3, 1652-1660. 

Frece, V. (2006) QSAR analysis of antimicrobial and haemolytic effects of cyclic cationic antimicrobial peptides derived from protegrin-1. Bioorgan. Medic. Chem. 14, 6065-6074. 

Bader, M.W., Navarre, W.W., Shiau, W., Nikaido, H., Frye, J.G., McClelland, M., Fang, F.C., Miller, S.I. Regulation of Salmonella typhimurium virulence gene expression by cationic antimicrobial peptides. Mol Microbiol 50 (2003) 219-230. 

Ara4 4-amino-4-deoxy-L-arabinose (also abbreviated as 4-aminoarabinose) CAMP cationic antimicrobial peptide Hep I heptose I Hep n heptose II... 

Moskowitz, S., Ernst, R., Miller, S. PmrAB, a two-component regulatory system of Pseudomonas aeruginosa that modulates resistance to cationic antimicrobial peptides and addition of aminoarabinose to lipid A. J Bacteriol 186 (2004) 575-579. 

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