MexAB-OprM efflux pump

Fig. 13.8 Schematic diagram of the MexAB-OprM efflux pump from Pseudomonas aeruginosa. (Kindly supplied by K. Poole.)...

Nakae, T., Nakajima, A., Ono, T., Saito, K., and Yoneyama, H. (1999) Resistance to beta-lactam antibiotics in Pseudomonas aeruginosa due to interplay between the MexAB-OprM efflux pump and beta-lactamase. Antimicrobial Agents and Chemotherapy, 43 (5), 1301-1303. 

Middlemiss, J.K. and Poole, K. (2004) Differential impact of MexB mutations on substrate selectivity of the MexAB-OprM multidrug efflux pump of Pseudomonas aeruginosa. Journal of Bacteriology, 186 (5), 1258-1269. 

Nakayama, K., Ishida, Y, Ohtsuka, M., Kawato, H., Yoshida, K., Yokomizo, Y, Hosono, S., Ohta, T, Hoshino, K, Ishida, H., Renau, T.E., Leger, R., Zhang, J.Z., Lee. V.J.. and Watkins, W.J. (2003) MexAB-OprM-specific efflux pump inhibitors in Pseudomonas aeru nosa. Part 1. Discovery and early strategies for lead optimization. Bioorganic Medicinal Chemistry Letters, 13 (23). 4201-4204. 

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