Proteins clinical aspects

Protein Metabolism Fat Metabolism Steroid Metabolism Clinical Aspects Side Effects Other Aspects... 

In light of these developments, we felt that it was necessary to review the content of the first edition and to update or supplement the information presented in this work. The new topics examined in this edition include (1) enzymatic synthesis and resolution of enantiomerically pure compounds (Chapter 8) (2) toxicological consequences and implications of stereoselective biotransformations (Chapter 9) (3) stereoselective transport across epithelia (Chapter 10) and (4) assessment of bioavailability and bioequivalence of stereoisomeric drugs (Chapter 11). The chapter on stereoselective protein binding (Chapter 12) has been completely revmtten and new contributions are presented on the regulatory, industrial, and clinical aspects of stereoisomeric drugs (Chapters 13-16). In addition, the chapters... 

It wiU be evident from the section on processes of digestion and absorption that the pancreas plays a central role in the absorptive process for carbohydrates, fats, and proteins. Disorders of the exocrine pancreas are therefore frequently associated with GI symptoms of malabsorption or diarrhea. In this section, pediatric and adult exocrine pancreatic disorders are briefly discussed and tests for assessing exocrine pancreatic function are described. Information on exocrine pancreatic tumors can be found in the later section on GI regulatory peptides. Recent textbooks on gastroenterology or medicine have more detail on the clinical aspects of exocrine pancreatic disorders. 

Cammack, R. Functional Aspects of Iron-Sulfur Proteins. In Metalloproteins Structure, Function and Clinical Aspects (ed. Weser, V.), Stuttgart, Thieme 1979, pp. 162-184... 

Case Study 6 Rationally Designed Isoform Selective Inhibitor Exhibiting a New Clinical Aspect of the Protein Target (Viagra and PDE5)... 

Tash, J.S. (1990). Role of cAMP, calcium, and protein phosphorylation in sperm motility, in Controls of Sperm Motility Biological and Clinical Aspects (C. Gagnon, ed.), pp. 229-240. CRC Press, Boca Raton, PT.. 

Amino acid analysis is important not only from a clinical aspect— amino acid metabolism disorders can be fatal if not diagnosed early—but also as the basis for protein and peptide sequencing. Due to the combination of the small amounts of material used in an actual analysis and the lack of chromophores on most amino acid residues, derivatization is common practice. Derivatization may be done prior to either separation or detection. 

MAb therapy may also cause acute hypersensitivity reactions that are primarily mediated by IgE. Anaphylactic reactions following administration of proteins can occur. Medications for the treatment of severe hypersensitivity should be available for immediate use. Additionally, antibodies of the IgG or IgM class may develop, resulting in delayed hypersensitivity reactions or neutralization of the effects of the therapeutic MAbs (49). Autoimmunity may also develop during the course of MAb therapy. For example, Remicade therapy has been associated with anti-DNA antibodies and lupus-like symptoms (Centocor, Inc., Remicade prescribing information, 2(X)0). Other safety-related clinical aspects of MAb therapy include consideration of secondary exposure of a fetus or nursing child. Antibodies can be excreted in breast milk, and IgG molecules, which make up the majority of the therapeutic MAbs, are known to cross the placental barrier. 

Solution equilibria for gadolinium imaging agents have been studied with consideration for pharmacokinetic, protein binding, elimination, and safety aspects of the dmgs. The thermodynamic stability constant, Kq defined by equation 7.4 must be large for clinically viable agents. Some Kq l data are listed in Table 7.3. 

Although most work to date has focused on the enzyme inhibition aspect, it is possible that the monoclonal VAP-1 antibody discussed above may well be closer to the clinic. The task of designing small molecules to interfere with cell-cell recognition is certainly feasible, but this will not be a trivial effort, more akin to the search for selective selectin antagonists which has proven to be very challenging. As confidence grows in the pharmaceutical industry that SSAO/VAP-1 is a validated target, it is inevitable that considerable resources will be directed to all avenues to block the functional action of this protein. 

Malabsorption Syndrome, with Special Reference to the Effects of Wheat Gluten (Frazer), 5, 69 Mellituria, Nonglucose (Sidbury), 4, 29 Microbiological Assay Methods for Vitamins (Baker and Sobotka), 5, 173 Organic Acids in Blood and Urine (Nordmann and Nordmann), 4, 53 Paper Electrophoresis Principles and Techniques (Peeters), 2, 1 Paper Electrophoresis of Proteins and Protein-Bound Substances in Clinical Investigations (Owen), I, 238 Parathyroid Function and Hyperparathyroidism, Biochemical Aspects of (Nordin), 4, 275... 

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