Protein synthesis activation

Cole et al., 1998) are likely to become more widespread. Instrument formats that feature high resolution chromatography and/or mass spectrometry may provide the required structural detail in some instances. Similar to small molecule analysis, the widespread use of open-access LC/MS systems for protein synthesis activities (Burdick and Stults, 1997) appears to be imminent. 

Mupirocin is a naturally occurring antibiotic available as a cream or ointment, and is unusual in its origin and mechanism of action. It inhibits protein synthesis, actively preventing the incorporation... 

Wound healing effect of carnosine is potentiated by zinc [35,91]. Its mechanism probably related to ability of carnosine to support functional activity of lymphocytes [61], to reveal the immunomodulating activity depending on age of animals and concentration of carnosine [86,92], to neutralize ROS formed in the inflammatory area. In some cases, increased formation of granulating tissues was noted which stimulated healing of damaged surface because of protein synthesis activation [86,88]. 

Exact mechanism unclear alkylation most likely mechanism, but does not cause DNA cross-linking also appears to inhibit DNA, RNA, and protein synthesis activated by hepatic microsomal mixed function oxidases (CYP450 enzymes) Alkylating agent cross-links DNA strands activated in the liver by microsomal (CYP450) mixed function oxidases... 

BSs protected cereal leaf cells from heat shock or saline stress. Leaf pre treatment with BSs decreased cell ultrastructure degradation from heat shock and high salt conditions. BSs increased HSG formation which is supposed to protect preformed mRNA in plant cells during heating. BSs enhanced heat shook resistance of the leaf protein-synthesizing system. The effect of BSs on RNA and protein synthesis was shown earlier (14). We observed protein synthesis activation in wheat leaves by BSs in normal and under stress conditions. Two-dimensional SDS-FAAGE of dS-methionine labeled proteins demonstrated BS-induced changes in the set of polypeptides synthesized in leaves and in the rate of their synthesis. 

Skowerski M, Konecki J, Czechowicz K, et al. 1997b. Effects of interaction between cadmium and selenium on hepatic metabolism in mice. Part I The study on DNA, RNA and protein synthesis activities in mouse hepatocytes. Med Sci Monit 3(5) 642-647. 

Protein synthesis was observed in the pyruvate-only system. However, addition of cofactors involved in pyruvate processing (0.33 mM NAD, 0.27 mM coenzyme A) enhanced protein synthesis to 70% of that observed when a PEP/pyruvate kinase (2) secondary energy store was used. Furthermore, supplying these cofactors and a PEP synthetase inhibitor (oxalate) to a PEP/pyruvate kinase batch reaction substantially improved ATP regeneration and protein synthesis activity. 

Figure 2. Incorporation rates related as percentage to the controls ( ) of [methyU Hjthy-midine (left), [5- H]uridine (middle), and h-[4,5- H]leucine (right) as a measure of the DNA, RNA, and protein synthesis activities respectively after a 90-min treatment of EAT cells with vanadocene...

LEVIN, D. and LONDON, I.M. Regulation of protein synthesis Activation by double-stranded RNA of a protein kinase that phosphorylates eukaryotic initiation factor 2. Proc. Natl. 

During the past few years ribosomes have been identified in a variety of mitochondria, although their exact dimensions have not yet been established. Ribo-somal-type RNA isolated from mitochondria have sedimentation properties different from those of extramitochondrial ribosomal RNA. As for the other components of the machinery for protein synthesis, activating enzymes for a variety... 

Hunt, T., Herbert, P., Campbell, E. A., Delidakis, C., and Jackson, R. J., 1983, The use of affinity chromatography on 2 5 ADP-sepharose reveals a requirement for NADPH, thioredoxin and thioredoxin reductase for the maintenance of high protein synthesis activity in rabbit reticulocyte lysates, Eur. J. Biochem. 131 303. 

Lee, C.C., Cantor, C.R., and WLttmanruLiebold, B., 1981, The number of copies of ribosome-bound proteins L7 and L12 required for protein synthesis activity, J. Biol. Chem., 256 41. 

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