Protein polymorphism

Acquired human prion diseases include kuru and variant CJD 794 Prion protein polymorphism contributes genetic susceptibility to prion disease 794... 

Protein Polymorphism Function Therapy Clinical Significance... 

Benes P, Muzik J, Benedik J, Elbl L, Vasku A, Siskova L, Znojil V, Vacha J. The C766T low-density lipoprotein receptor related protein polymorphism and coronary artery disease, plasma lipoproteins, and longevity in the Czech population. J Mol Med 2001 79 116-120. 

Species specificity of phenotypes has been little studied through the physiological or biochemical approach because of insufficient knowledge of their adaptive role. While the many papers on protein polymorphism are important in the context of population genetics, they cannot yet contribute to the progress... 

Consider a polymorphic site, S, for which there are a set of positions P P , P2, P3, Pk,.. . Pr where protein polymorphisms are possible, at each position, Pk, there is a set of possible residues R (Rx, R2, R3, Rk,... Rs if a particular residue, Rk, at position, Pk, is absent or replaced within a patient and that residue is believed to contribute significantly to the activity of the current drug molecule, then that patient will show a marked difference in affinity for the drug. In a crude... 

Most work on protein polymorphism in cestodes has undoubtedly been performed with the hydatid organisms Echinococcus spp., because their identification presents a number of challenging problems. The life cycles involve various hosts while much inter- and intra-specific variation occurs and this has important implications for the epidemiology of hydatid disease (495, 501, 865). 

Oxford, G. S. Rollinson, D. (eds.) (1983). Protein polymorphism adaptive and taxonomic significance. The Systematics Association Special Volume no. 24. Academic Press London. 

Kimura, M. (1982). Molecular Evolution, Protein Polymorphism, and the Neutral Theory Springer-Verlag, Berlin and Japan Scientific Societies Press, Tokyo. 

Alper CA, Johnson AM. Immunofixation electrophoresis A technique for the study of protein polymorphism. Vox Sang 1969 17 445-52. 

Anderson LC, Lamberts BL, Bmton WF Salivary protein polymorphisms in caries-free and... 

Central dogma of molecular biology formulated Protein polymorphism established Human chromosomes enumerated Disease associated with chromosomal aberrations Experimental pharmacogenetics emerges... 

Schatzl HM, Wopfner L, Gilch S et al (1997) Is codon 129 of prion protein polymorphic in human beings but not in animals Lancet 349 1603-1604... 

Johnson C, Johnson J, Vanderloo JP et al (2006) Prion protein polymorphisms in white-tailed deer influence susceptibility to chronic wasting disease. J Gen Virol 87 2109-2114... 

Thorpe JP. Enzyme variation, genetic distance and evolutionary divergence in relation to levels of taxonomic separations. In Oxford GS, Rollinson D, eds. Protein Polymorphism Adaptive and Taxonomic Significance. New York Academic Press, 1983, pp 131-152. 

Zhang X, Leung FC, Chan DK, YangG, Wu C (2002). Genetic diversity of Chinese native chicken breeds based on protein polymorphism, randomly amplified polymorphic DNA, and microsatellite polymorphism. Poult. Sci, 81(10) 1463-1472. 

Figure 5. Mapping of protein polymorphisms by mass spectrometry. A Major Urinary Protein from Mus spretus was purified and Lys-C digestion fragments were mass measured by MALDl-ToF mass spectrometry. Four of the peptides had the same masses as the equivalent protein from Mus domesticus. However, for two of the remainder, of novel mass, tandem mass spectrometry led to the identification of an amino acid change that was consistent with the new peptide mass. (J is used to define leucine or isoleucine, which cannot be distinguished by this type of mass spectrometry).

Cain A J (1983) Concluding remarks. In Protein Polymorphism Adaptive and Taxonomic Significance (ed G S Oxford and D Rollinson) pp 391-7. Academic Press, London and New York. 

Nei M, Graur D (1984) Extent of protein polymorphism and the neutral mutation theory. Evol Biol 17 73-118 Nei M, Stephens JC, Saitou N (1985) Methods for computing the standard errors of branching points in an evolutionary tree and their application to molecular data from humans and apes. Mol Biol Evol 2 66-85... 

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