Prion diseases protein polymorphism

Acquired human prion diseases include kuru and variant CJD 794 Prion protein polymorphism contributes genetic susceptibility to prion disease 794... 

Baker HE, Poulter M, Crow TJ et al (1991) Aminoacid polymorphism in human prion protein and age at death in inherited prion disease. Lancet 337 1286... 

Johnson C, Johnson J, Vanderloo JP et al (2006) Prion protein polymorphisms in white-tailed deer influence susceptibility to chronic wasting disease. J Gen Virol 87 2109-2114... 

Prion diseases occur through different strains, as evidenced by different progression patterns and clinical features of the disease that seem to be associated with different genetic and/or post-translational polymorphisms in the prion protein, yet how these differences translate into different disease outcomes remains unknown. 

R, Montagna, R, Ghetti, B., Goldfarb, L.G., Gajdusek, D.C., Lugaresi, E., Gambetti, R., and Autilio-Gambetti, L. (1994). Fatal familial insomnia and familial Creutzfeldt-Jakob disease different prion proteins determined by DNA polymorphism. Proc. Natl. Acad. Sci. U.S.A. 91, 2839-2842. 

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