Protein homologs

P Koehl, M Delame. A self consistent mean field approach to simultaneous gap closure and side-chain positioning m protein homology modelling. Nature Struct Biol 2 163-170, 1995. R Samudrala, J Moult. A graph-theoretic algorithm for comparative modeling of protein structure. J Mol Biol 279 287-302, 1998. 

HMG CoA-Reductase HMG-CoA-Reductase Inhibitors Homologous Desensitization Homologous Proteins Homologous Recombination Homology Modeling Hormonal Contraceptives Hormone Replacement Therapy (HRT)... 

Hallett, P., Mehlert, A., Maxwell, A. (1990). E. colt cells resistant to the DNA gyrase inhibitor, ciprofloxacin, overproduce a 60 IcD protein homologous to GroEL. Mol. Microbiol. 4,345-353. 

Afzelins L, Zamora I, RidderstromM, AnderssonTB, Karlen A, Masimirembwa CM. Competitive CYP2C9 inhibitors enzyme inhibition stndies, protein homology modeling, and three dimensional qnantitative strnctnre activity relationship analysis. Mol Pharmacol 2001 59 909-19. 

Wang Q, Halpert JR. Combined three-dimensional qnantitative strnctnre-activity relationship analysis of cytochrome P450 2B6 snbstrates and protein homology modeling. Drug Metab Dispos 2002 30 86-95. 

Cavalli A, Greco G, Novellino E, Recanatini M. Linking CoMFA and protein homology models of enzyme-inhibitor interactions an application to nonsteroidal aromatase inhibitors. Bioorg Med Chem 2000 8 2771-80. 

Bieszke, J. A., E. L. Braun et al. (1999). The nop-1 gene of Neurospora crassa encodes a seven transmembrane helix retinal-binding protein homologous to archaeal rhodopsins. Proc. Natl. Acad. Sci. 96(14) 8034-8039. 

Alpy, F., Stoeckel, M. E., Dierich, A. et al. 2001. The steroidogenic acute regulatory protein homolog MLN64, a late endosomal cholesterol-binding protein. J. Biol. Chem., 276(6) 4261-4269. 

Tweedie, S., Grigg, M.E., Ingram, L. and Selkirk, M.E. (1993) The expression of a small heat-shock protein homolog is developmentally-regulated in Nippostrongylus brasiliensis. Molecular and Biochemical Parasitology 61, 149—154. 

Ukaji N, Kuwabara C, Takezawa D, Arakawa K, Yoshida S, Fujikawa S. Accumulation of small heat shock protein homologs in the endoplasmic reticulum of cortical parenchyma cells in mulberry in association with seasonal cold acclimation. Plant Physiol 1999 120 481-490. 

Zhang, Y., Schuetz, J.D., Elmquist, W.F. and Miller, D.W. (2004) Plasma membrane localization of multidrug resistance-associated protein homologs in brain capillary endothelial cells. Journal of Pharmacology and Experimental Therapeutics, 311, 449-455. 

IB Insulin growth factor-binding protein homologs E(M) 0(0) 0(0) 1BOE... 

Homologous proteins. Homologous proteins usually crystallize under very different conditions. For example, in our laboratory two homologous proteins crystallize in either 10 mM sodium acetate, pH 3.8, 5 mM DTT, and 50% (v/v) MPD (Weichsel et al, 1996), or 100 mM ammonium sulfate, 30% PEG 6000, and 10 mM DTT (Filson et al, 2003). This technique was first used by Kendrew for solving the structure of sperm whale myoglobin (Kendrew et al., 1954) and has been used in many other structural studies. Currently, this technique is heavily exploited in membrane protein crystallography (Wiener,... 

Deletion of the regulatory nirQ gene results simultaneously in a loss of the ability to reduce both nitrite and NO in P. stutzeri (Braun and Zumft, 1992). Nitrite reductase is synthesized and is active in vitro but nitric oxide reductase is synthesized in an inactive form. Although the exact function of the nirQ gene product is unknown, the gene encodes a protein homologous with the NtrC family of transcriptional activators (Zumft, 1993). 

Pailhoux EA, Martinez A, Veyssiere GM, Jean CG. Androgen-dependent protein from mouse vas deferens cDNA cloning and protein homology with the aldo-keto reductase superfamily. J Biol Chem 1990 265 19932-19936. 

A characterization of the translocase complexes responsible for mitosomal protein import in Giardia is under way. An iterative BLAST search of the G. intestinalis genome was employed for the identification of the import machinery components. The only candidate to have been found so far is GiPAMIS, a mitosomal protein homologous to mitochondrial presequence translocase-associated motor 18 (Dolezal et al. 2005). 

Bhisutthibhan, J., Pan, X.-O., Hossler, P.A., Walker, D.J., Yowell, C.A., Carlton, J., Dame, J.B., and Meshnick, S.R. The plasmodium falciparum translationally controlled tumor protein homolog and its reaction with the antimalarial drug artemisinin,. Biol. Chem., 273,16192,1998. 

Although most exported bacterial proteins use this pathway, some follow an alternative pathway that uses signal recognition and receptor proteins homologous to components of the eukaryotic SRP and SRP receptor (Fig. 27-33). 

It has been suggested that brown adipose tissue may also function to convert excess dietary fat into heat and thereby to resist obesity.k m Mice lacking the gene for the mitochondrial uncoupling protein are cold-sensitive but not obese. However, other proteins, homologous to UCP1, have been discovered. They may partially compensate for the loss.m,h... 

Most of the proteins of mitochondria are encoded in nuclear DNA and are synthesized on cytoplasmic ribosomes. Mitochondria do not utilize proteins homologous to those of the bacterial Sec system but have their own set of transport proteins.603-605 These proteins, which include an outer membrane complex (Tom) and an inner membrane complex (Tim), are discussed in Chapter 18 (see Fig. 18-4). Perhaps these specialized mitochondrial proteins are needed because transport into the mitochondrial matrix is in an opposite direction to the transport out through bacterial membranes. 

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