Small heat shock proteins

Osterreich, S., Schunck, H., Benndorf, R., Bielka, H. (1991). Cisplatin induces the small heat shock protein hsp25 and thermotolerance in Ehrlich ascites tumor cells. Biochem. Biophys. Res. Comm. 180,243-248. 

Tweedie, S., Grigg, M.E., Ingram, L. and Selkirk, M.E. (1993) The expression of a small heat-shock protein homolog is developmentally-regulated in Nippostrongylus brasiliensis. Molecular and Biochemical Parasitology 61, 149—154. 

Ukaji N, Kuwabara C, Takezawa D, Arakawa K, Yoshida S, Fujikawa S. Accumulation of small heat shock protein homologs in the endoplasmic reticulum of cortical parenchyma cells in mulberry in association with seasonal cold acclimation. Plant Physiol 1999 120 481-490. 

Takahashi T, Komeda Y. (1989) Characterization of two genes encoding small heat-shock proteins in Arabidopsis thaliana. Mol Gen Genet 219 365-372. 

Sule, A., Vanrobaeys, R, Hajos, G., Van Beeumen, J., and Devreese, B., Proteomic analysis of small heat shock protein isoforms in barley shoots. Phytochemistry 65(12), 1853-1863, 2004. 

The role of the IF, and particularly the keratin filament system, in resisting the forces of mechanical stress has been well established. However, IFs also play a role in countering metabolic stress. Perhaps the best example is the cytoprotective role played by the simple epithelial keratins, K8/18. However, vimentin, desmin, peripherin, GFAP, the lens proteins phakinin, and filensin and other keratins have also been shown to associate with members of the small heat shock protein (HSP) family, including HSP27 and aB-crystallin (reviewed in Coulombe and Wong, 2004 Marceau et al., 2001 Nicholl and Quinlan, 1994). 

Acarin L., Paris J., Gonzalez B., and Castellano B. (2002). Glial expression of small heat shock proteins following an excitotoxic lesion in the immature rat brain. Glia 38 1-14. 

The cardioprotective actions of the small heat shock proteins are by now well established (Chi and Karliner 2004). However, how they confer protection is still unclear. Among others, they may act as chaperones (Georgopolous and Welch 1993),... 

Martin, J.L., Mestril, R., Hilal-Dandan, R., Brunton, L.L., and Dillmann, W.H. 1997. Small heat shock proteins and protection against ischemic injury in cardiac myocytes. Circulation 96 4343-4348. 

Sun Y, MacRaeTH. Small heat shock proteins Molecular structure and chaperone function. Cell Mol Life Sci 2005 62, pp. 2460-2476. 

Sun Y, MacRaeTH.The small heat shock proteins and their role in human disease. FEBS J 2005 272, pp. 2613-2627. 

Trougakos IP, Gonos ES. Regulation of clusterin/apolipoprotein J, a functional homologuetothe small heat shock proteins, by oxidative stress in ageing and age-related diseases. Free Radic Res. 2006 40 1324-1334. 

Chaperones (small heat shock proteins, sHSPs Hsp90 inhibitors and HSP inducers) Chemokines... 

Chaperones (Small Heat Shock Proteins, sHSPs)... 

De Nobel, H., Lawrie, L., Brul, S., et al. 2001. Parallel and comparative analysis of the proteome and transcriptome of weak-acid adapted Saccharomyces cer-evisiae reveals a crucial function for the small heat-shock protein Hsp26. Yeast 18 1413-1428. 

IHC reveals that RFs contain alpha B-crystallin, stain with ubiquitin, and are centrally GFAP negative (see Fig. 20.12A). Alpha B-crystallin is a lens protein in the small heat-shock protein family. When abundant, RFs are easily appreciated on H E stain. IHC is most needed when... 

Hitotsumatsu T, Iwaki T, Fukui M, et al. Distinctive immunohistochemical profiles of small heat shock proteins (heat shock protein 27 and alpha B-crystallin) in human brain tumors. Cancer. 1996 77 352-361. 

STRUCTURE AND FUNCTION OF THE SMALL HEAT SHOCK PROTEIN/a-CRYSTALLIN FAMILY OF MOLECULAR CHAPERONES... 

The small heat shock proteins (sHsps) and the structurally related vertebrate eye lens a-crystallins have been the poor cousins in the family... 

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