Proteins sequence homology

SY Chung, S Subbiah. A structural explanation for the twilight zone of protein sequence homology. Structure 4 1123-1127, 1996. 

K Sjdlander, K Karplus, M Brown, R Hughey, A Krogh, IS Mian, D Haussler. Dirichlet mixtures A method for improved detection of weak but significant protein sequence homology. Comput Appl Biosci 12 327-345, 1996. 

The four major classes or families of mammalian G proteins (Gj, G, G, and G,2) are based on protein sequence homology. Representative members of each are shown, along with known stimuli, effectors, and well-defined biologic effects. Nine isoforms of adenylyl cyclase have been identified (isoforms l-IX). All isoforms are stimulated by a inhibit types V and Vi, and Oq inhibits types I and V. At least 16 different a subunits have been identified. 

The molybdenum and tungsten centers are classified by the coordination of their MVI states and sorted into enzyme groups based on protein sequence homology. There are four distinct subfamilies of enzymes, which are based on... 

Respiratory nitrate reductase has considerable protein sequence homology with dmso reductases and formate dehydrogenases. Both preliminary crystallographic... 

Protein sequence homology suggests that sulfite oxidase and assimilatory nitrate reductase are members of the same molybdenum enzyme subfamily [31]. Consistent with this classification, the cofactors of sulfite oxidase and assimilatory nitrate reductase differ significantly from those in dmso reductase, aldehyde oxido-reductase, xanthine oxidase (see Section IV.E.), and even respiratory nitrate reductase (Section IV.D). The EXAFS of both sulfite oxidase [132-136] and assimilatory nitrate reductase [131,137,138] and x-ray studies of sulfite oxidase (chicken liver) [116] confirm that the molybdenum center is coordinated by two sulfur atoms from a single MPT ligand and by the sulfur atom of a cysteine side chain. The Movl state is bis(oxido) coordinated (Figure 14). 

W. T. Thylor. Identification of protein sequence homology by consensus template alignment./. MoL Biol. 755 233-258 (1986). 

Otaka, E and Ooi, T. (1987) Examination of Protein Sequence Homologies IV Twenty-Seven Bacterial Ferredoxins, Journal of Molecular Evolution, 26, 257-268. 

TABLE 9.3 FcsRI-alpha protein sequence homology across species... 

Mewes HW, Albermann K, Bahr M, Frishman D, Gleissner A, Hani J, Heuman K, Kleine K, Maierl A, Oliver SG, Pfeifer F, Zollner A Overview of the yeast genome. Nature 1997 387 7-65. Mewes HW, Albermann K, Heumann K, Liebl S, Pfeifer F MIPS A database for protein sequences, homology data and yeast genome information. Nucleic Acid Res 1997 35 28-30. Clarke L, Baum MP Functional analysis of a centromere from fission yeast A role for centromere-specific repeated DNA sequences. Mol Cell Biol 1990 10 1863-1872. 

Schroder J. Protein sequence homology between plant 4-coumarate CoA ligase and firefly luciferase. Nucleic Acids Res 1989 17 460. 

Figure 15. Localization of protein functions as suggested by both the mutagensis studies of Ross, Shewchuk, and their co-workers (164,171-173) and protein sequence homology analyses (143, 144, 210).

PROT-FAM Protein sequence homology database http //www.mi ps.biochem.mpg.de/des(Y protfanV... 

Sharief, F.S., Lee, H., Leuderman, M.M., Lundwall, A., Deaven, L.L., Lee, C., and Li, S.S.L., 1989, Human prostatic acid phosphatase cDNA cloning, gene mapping and protein sequence homology with lysosomal acid phosphatase. Biochem. Biophys. Res. Commun. 160 79-86. 

---