Propionic 3-chloro

Related Reagents. 10,2-Camphorsultam (/ )-2-t-Butyl-6-methyl-4//-l,3-dioxin-4-one (/ )-(+)-(t)-Butyl 2-(/ -Tolysulfin-yl)propionate Chloro(cyclopentadienyl)bis[3-0-( 1,2 5,6-do-0-isopropylidene-a-D-glucofuranosyl)]titanium lO-Dicyclohexyl-sulfonamidoisobomeol Diisopinocampheylboron Trifluoro-methanesulfonate (R,/ )-2,5-Dimethylborolane 2-Hydroxy-... 

Chloro-9-fluoro-llb-hydroxy-16b-methyl-17-(l-oxopropoxy)-pregna-l,4-diene-3,20-dione. See Clobetasol propionate. 

Substitution, All lation, and Rearrangement. The reaction of alkaline phenoxides with alkyl 3 -2-(chloro)- or 3 -2-(mesyloxy)propionate gives optically active R-2-aryloxyaIkanoic acid esters in good chemical and optical yields (>97% ee) (51—53) ... 

CHLORO-2,2,3-TRIFLUOROPROPIONIC ACID (Propionic acid, 3-chloro-2,2,3-trifluoro-)... 

Chloro-2,2,3-trifluoropropionic acid has been prepared by permanganate oxidation of 3-chloro-2,2,3-trifluoropropanol which is one of the telomerization products of chlorotrifluoroethylene with methanol. The present procedure is a modification of one reported earlier and is undoubtedly the method of choice for making propionic acids containing 2 fluorine atoms, i.e., 2,2,3,3-tetrafluoropropionic acid, 3,3-dichloro-2,2-difluoropropionic acid, and 3-bromo-2,2,3-trifluoropropionic acid. When preparing 2,2,3,3-tetrafluoropropionic acid from tetrafluoroethylene, it is desirable to use an additional 50 ml. of acetonitrile and externally applied heat to initiate the reaction. 

Chlorobenzene Producers Association (CPA), 270 p-Chlorobenzotrichloride, 39 Chlorobenzotrifluorides, 39 Chlorobromomethane, 39 Chlorodifluorobromomethane, 39 Chlorodifluoroethane, 39 Chlorodifluoromethane, 39 Chlorodiphenyl, 39 Chloroethanol, 39 2-Chloroethyl vinyl ether, 39 Chlorofluorocarbons, 39 Chloroform, 40 Chloromethyl anilines, 40 Chloromethyl ether, 40 Chloromethyl methyl ether, 40 2-(4-Chloro-2-methylphenoxy) propionic acid, 40 Chloromethyl phenyl isocyanate, 40... 

In 1909, Thiele and Landers reported the synthesis of p- (3-methoxy-isoxazol-5-yl)-propionic acid (77), from the corresponding chloride or bromide (76). In 1961, a similar reaction was reported for 3-chloro-5-arylisoxazoles, enabling the synthesis of 3-hydroxy-5-phenyl-... 

Somewhat milder oxidative conditions lead to loss of but one carbon. Periodic acid cleavage of the side chain in 65, leads to the so-called etio acid (66). Reaction with propionic anhydride leads to acylation of the 17-hydroxyl group (67). Possibilities for neighboring group participation severely limit the methods available for activating the acid for esterification. Best results seemed to have been obtained by use of a mixed anhydride from treatment with diphenyl chloro-... 

Figure 13.11 Column-switcliing RPLC trace of a surface water sample spiked with eight chlorophenoxyacid herbicides at the 0.5 p-g 1 level 1, 2,4-dichlorophenoxyacetic acid 2, 4-chloro-2-methylphenoxyacetic acid 3, 2-(2,4-diclilorophenoxy) propanoic acid 4, 2-(4-cliloro-2-methylphenoxy) propanoic acid 5, 2,4,5-trichlorophenoxyacetic acid 6, 4-(2,4-dichlorophenoxy) butanoic acid 7, 4-(4-chloro-2-methylphenoxy) butanoic acid 8, 2-(2,4,5-tiichlorophenoxy) propionic acid. Reprinted from Analytica Chimica Acta, 283, J. V. Sancho-Llopis et al., Rapid method for the determination of eight chlorophenoxy acid residues in environmental water samples using off-line solid-phase extraction and on-line selective precolumn switcliing , pp. 287-296, copyright 1993, with permission from Elsevier Science.

The excess of N-chlorosuccinimide is destroyed by the addition of about 15 drops of allyl alcohol and 180 ml of water is then added with stirring. This mixture is held at 0°C for about one hour. The precipitated 16/3-methyl-1,4-pregnadiene-9o-chloro-11/3,17o,21-triol-3,20-dione-21-acetate is recovered by filtration. A solution of 250 mg of the chlorohydrin in 5 ml of 0.25N perchloric acid in methanol is stirred for about 18 hours at room temperature to produce 16/3-methyl-9o-chloro-11/3,17o,21-trihydroxy-1,4-pregnadiene-3,20-dione which is recovered by adding water to the reaction mixture and allowing the product to crystallize. Propionic anhydride is then used to convert this material to the dipropionate. 

The mixture of 7.9 g of ethyl a-(4-aminophenyl)propionate and 8.3 g of ethyl 2-chloro-methylbenzoate is refluxed under nitrogen for one hour. The residue is recrystallized from hexane, to yield the ethyl a-[4-(1-oxo-isoindolino)-phenyl]-propionate of the formula... 

Ethyl a-(3-chloro-4-aminophenyl)-propionate hydrochloride 1,4-Dibromo-2-butene... 

To the mixture of 85.5 g ethyl a-(3chloro-4.aminophenyl)-propionate hydrochloride, 142 g sodium carbonate and 600 ml dimethyl formamide, 107 g 1,4room temperature. The mixture is filtered, the filtrate evaporated in vacuo, the residue is triturated with hexane, the mixture filtered, the residue washed with petroleum ether and the filtrate evaporated. The residue is combined with 280 ml 25% aqueous sodium hydroxide and the mixture refluxed for 8 hours. After cooling, it is diluted with water, washed with diethyl ether, the pH adjusted to 5 to 5.2 with hydrochloric acid and extracted with diethyl ether. The extract is dried, filtered, evaporated and the residue crystallized from benzene-hexane, to yield the a-(3-chloro-4-pyrrolinophenyl)-propionic acid melting at 94°C to 96°C. 

The general plan of Organic Syntheses has been discussed in the prefaces of the previous volumes. In this volume are published two distinctly different methods of preparation for each of two compounds. The directions for producing /3-chloro-propionic acid first from acrolein and second from trimethylene chlorohydrin, and for producing trimethylacetic acid first from terJ-butyl chloride and second from pinacolone, have been included. This has been deemed advisable since in some countries one raw material is more readily available than the other. 

C25H32CIFO5 66852-57-1) see Ulobetasol propionate 21-chloro-9p,lip-epoxy-16P-methyl-17-propionyloxy-pregn-4-ene-3,20-dione... 

C25H33CIO5 66852-55-9) see Ulobetasol propionate 5-chloro-A-ethoxycarbonyl-2-methylaniline... 

C25H27CIO3 /O/Oy-i -J) see Trenbolone acetate ( )-2-chioro-3-[4-[(6-hydroxy-2,5,7,8-tetramethyl-chroman-2-yl)incthoxy]phenyl]propionic acid (C23H27C10 97322-69-5) sec Troglitazone 4 -chloro-2 (24midazoUn-2-yl)benzophenone (Ci HjiClNjO 22590-J7-6) see Mazindo ... 

Natural systems may be quite complex. For example, the enantiomerization of phenoxyalkanoic acids containing a chiral side chain has been studied in soil using H20 (Buser and Muller 1997). It was shown that there was an equilibrium between the R- and 5-enantiomers of both 2-(4-chloro-2-methylphenoxy)propionic acid (MCPP) and 2-(2,4-dichlorophenopxy)propionic acid (DCPP) with an equilibrium constant favoring the herbicidally active / -enantiomers. The exchange reactions... 

A facultatively anaerobic organism designated Anaeromyxobacter dehalogenans (Sanford et al. 2002) was capable of dechlorinating ortho-chlorinated phenols using acetate as electron donor—2-chlorophenol was reduced to phenol and 2,6-dichlorophenol to 2-chloro-phenol (Cole et al. 1994). A strain of Desulfovibrio dechloracetivorans was also able to couple the dechlorination of ortho-substituted chlorophenols to the oxidation of acetate, fumarate, lactate, and propionate (Sun et al. 2000). 

Zipper C, K Nickel, W Angst, H-PE Kohler (1996) Complete microbial degradation of both enantiomers of the chiral herbicide Mecoprop [(R,S)-2-(4-chloro-2-methylphenoxy)]propionic acid in an enantioselective manner by Sphingomonas herbicidovorans sp. nov. Appl Environ Microbiol 62 4318-4322. 

Clomeprop Parent and 2-(2,4-dichloro-3-methylphenoxy)propionic acid Naproanilide Parent and 2-(2-naphthoxy)propionic acid Propanil Parent and 3,4-dichloroaniline Pentanochlor Parent and 3-chloro-4-methylaniline Etobenzanid Parent... 

ABA triblock copolymers, where A was PBd and B either PS or PMMA were prepared by the combination of ROMP and ATRP techniques [122], The PBd middle blocks were obtained through the ROMP of cyclooctadi-ene in the presence of l,4-chloro-2-butene or cis-2-butene-l,4-diol bis(2-bromo)propionate using a Ru complex as the catalyst. The end allyl chloride or 2-bromopropionyl ester groups were subsequently used for the ATRP of either styrene or MMA using CuX/bpy (X = Cl or Br) as the catalytic system (Scheme 50). Quantitative yields but rather broad molecular weight distributions (Mw/Mn higher than 1.4) were obtained. 

A mild and efficient a-heteroarylation of simple esters and amides via nucleophilic aromatic substitution has been described <06OL1447>. Treatment of 2-chloro-benzo[//Jthiazole 99 with tert-butyl propionate in the presence of NaHMDS under nitrogen furnishes tert-butyl 2-(benzo[c(jthiazol-2-yl)propanoate 100. When the same reaction is preformed initially under nitrogen and then exposed to air, the hydroxylation product 101 is obtained. This method offers two desirable features that are either complementary or improvements to the palladium-catalyzed a-arylation reactions. First, heteroaryl chlorides... 

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