Principal importer definition

If no entity clearly meets the definition of principal importer, the EPA will designate the company that must file the PMN, with all its attendant responsibilities/ ... 

If a significant new use relates to import, the principal importer of a substance subject to a SNUR is required to file a SNUN. The principal importer is defined as the first importer who, knowing that a chemical substance will be imported for a significant new use rather than manufactured in the United States, specifies the chemical substance and the amount to be imported. The definition adds that [o]nly persons who are incorporated, licensed, or doing business in the United States may be principal importers. ... 

It seems from the definition of principal importer that the principal importer must know that the substance will be used for a significant new use... 

The next group of alcoholic bodies to be studied are those which, although open-chaini alcohols, show considerable tendency to easily pass into closed-chain compounds, so that they occupy a definite position of their own, midway between the ordinary aliphatic series and the closed-chain series. The principal members of this important group are geraniol, nerol, linalol, and citronellol, together with the so-called aliphatic sesquiterpene alcohols, farnesol and nerolidol. 

It is important to recognize that the following analytical methods essentially determine EO-PO ratio ( H NMR, IR, cleavage methods) or even simply alkylene oxide content (compleximetric methods) of the analyte, and as such are not specific quantitative or qualitative methods for poloxamers, since EO-PO copolymers of a different structure (for instance, random copolymers, or PO-EO-PO block copolymers) may respond to the methods in a way indistinguishable from poloxamers. The principal technique that permits definitive identification of a sample as a poloxamer is C NMR, which allows structural details, such as the distribution of EO and PO units along the polymer chain, to be elucidated [10]. 

The principal relationship between packages is import. When you start a new piece of work, you almost never work from scratch there are at least all the primitive definitions (the numbers and so on). More usefully, you write an implementation against a corresponding specification package, and you write that specification by importing a corresponding domain model package. 

Importance of Interfaces. At one time, modularity in the software world was principally motivated by the need to divide a big job into manageable tasks. The interfaces of your module worked with the modules of the people in the neighboring cubicles it was easy to discuss any issues about the interfaces. In a culture that reuses the pieces, you are unlikely to know all the components that yours will connect to You must therefore be much more careful about your interface definitions (and about reading those of others). 

In order to extract some more information from the csa contribution to relaxation times, the next step is to switch to a molecular frame (x,y,z) where the shielding tensor is diagonal (x, y, z is called the Principal Axis System i.e., PAS). Owing to the properties reported in (44), the relevant calculations include the transformation of gzz into g x, yy, and g z involving, for the calculation of spectral densities, the correlation function of squares of trigonometric functions such as cos20(t)cos20(O) (see the previous section and more importantly Eq. (29) for the definition of the normalized spectral density J((d)). They yield for an isotropic reorientation (the molecule is supposed to behave as a sphere)... 

The principal limitation of these data is the lack of definition of the individual forms for the CYP2C subfamily. Analysis of this subfamily has remained problematic due to high cross-reactivities of all of the distinct forms with most antibody preparations. In addition, Western blot analysis does not distinguish between active and inactive forms of the protein. Furthermore, distinct enzymes may have different affinities for coenzymes necessary for catalytic activity, which will serve to unlink abundance of the protein and its catalytic activity. Therefore the assumptions must be made that the ratios of active to inactive protein are similar for all forms and that all forms have similar affinities for coenzymes. These assumptions may not be justified. However, even with these limitations, the study of Shimada et al. (1994) contributes greatly to our understanding of relative enzyme abundance in human liver. In addition, the relative abundance data, coupled with the absolute P450 content (per unit protein) and the turnover numbers for enzyme-specific substrates (per unit protein), can provide an estimate of the turnover number for individual enzymes in the human liver membrane environment. This provides an important benchmark for evaluation of turnover number data from cDNA-expressed enzymes. 

SALTS OF IKON.—It has been shown that iron is susceptible of two definite degrees of oxidisation, forming a protoxide—FeO—and a sesquioxlde — Fea Oa. Both those oxides are salifiable, giving rise to ferrous and feme Baits. The most important is the native protocarbonate, which constitutes the principal source of British iron, and has, therefore, been fully described in treating of the ores of this metal. 

Nonreceptor-Mediated Drug Action. At least one important class of drugs, the general anesthetics, has been assumed not to owe its therapeutic activities to a specific receptor process. Anesthetic potency shows an excellent linear correlation with partition coefficient and this has been extrapolated to a definition of action at a lipid site. The phospholipids of cell membranes, particularly nerve cells, have been considered as principal targets for general anesthetic action. It has been hypothesized... 

The purpose of this chapter is to remind the reader of the basis of the theory of elasticity, to outline some of its principal results and to discuss to what extent the classical theory can be applied to polymeric systems. We shall begin by reviewing the definitions of stress and strain and the compliance and stiffness matrices for linear elastic bodies at small strains. We shall then state several important exact solutions of these equations under idealised loading conditions and briefly discuss the changes introduced if realistic loading conditions are considered. We shall then move on to a discussion of viscoelasticity and its application to real materials. 

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