Precautions irritants

Handling, Storage, and Precautions irritant use only in a fume hood. 

Precautions Irritating to skin and eyes, causes lung and liver cancers, poison if consumed. Synonyms none listed. 

Precautions Irritant to eyes and skin. Flammable, dangerous fire risk. 

Precautions Irritating in concentrated form. Will react with moisture to form slaked lime. A strong alkali. An oxidizer. GRAS (generally recognized as safe) when used in moderate amounts. 

Precautions Irritating and burning sensation to nose and throat that cannot by alleviated by water. However, milk, sour cream or yogurt has cooling effect. 

Precautions Irritating to eyes and skin. A lachrymator (causes eyes to water). Flammable, a fire risk. 

Precautions Irritant to skin. Could cause allergic reaction. 

Precautions Irritating to skin, eyes, nose, and throat. Harmless when used for intended purposes. 

Precautions Irritant to respiratory tract, eye, and skin. Concentrated solutions can cause bums of the... 

Handling, Storage, and Precautions irritant gloves and safety goggles should be worn when bandting this oxidant avoid inhalation of dust and avoid contact of oxidant with combustible matter. 

Toxicology Causes immediate or delayed severe eye irritation TSCA listed Precaution Irritating fumes and organic acid vapors may develop when exposed to high temps, or open flame... 

Handling, Storage, and Precautions irritant and moisture sensitive. Incompatible with strong bases (see Aldrich safety index for Benzoyl Chloride). ... 

Propargyl alcohol is a primary skin irritant and a severe eye irritant and is toxic by all means of ingestion all necessary precautions must be taken to avoid contact with Hquid or vapors. The LD q is 0.07 mL/kg for white rats and 0.06 mL/kg for guinea pigs. 

Butynediol is a primary skin irritant and sensitizer, requiring appropriate precautions. Acute oral toxicity is relatively high LD q is 0.06 g/kg for white... 

There is a significant difference in the toxicological effects of saturated and unsaturated afiphatic aldehydes. As can be seen in Table 6, the presence of the double bond considerably enhances toxicity. The precautions for handling reactive unsaturated aldehydes such as acrolein, methacrolein [78-85-3] and crotonaldehyde should be the same as those for handling other highly active eye and pulmonary irritants, as, for example, phosgene. 

Maleic Anhydride. The ACGIH threshold limit value in air for maleic anhydride is 0.25 ppm and the OSHA permissible exposure level (PEL) is also 0.25 ppm (181). Maleic anhydride is a corrosive irritant to eyes, skin, and mucous membranes. Pulmonary edema (collection of fluid in the lungs) can result from airborne exposure. Skin contact should be avoided by the use of mbber gloves. Dust respirators should be used when maleic anhydride dust is present. Maleic anhydride is combustible when exposed to heat or flame and can react vigorously on contact with oxidizers. The material reacts exothermically with water or steam. Violent decompositions of maleic anhydride can be catalyzed at high temperature by strong bases (sodium hydroxide, potassium hydroxide, calcium hydroxide, alkaU metals, and amines). Precaution should be taken during the manufacture and use of maleic anhydride to minimize the presence of basic materials. 

Health and Safety Factors (Toxicology). No special precautions are necessary in the handling of malonic acid beyond normal safe handling measures. Due to its acidity malonic acid is classified as a mild irritant (skin irritation, rabbits). The LD q value (oral, rats) for malonic acid is 2750 mg/kg. Transport classification RID/ADR, IMDG-Code, lATA/lCAO not restricted. 

Health and Safety Factors. Dimethyl malonate and diethyl malonate do not present any specific danger of health ha2ard if handled with the usual precautions. Nevertheless, inhalation and skin contact should be avoided. Dimethyl malonate has a LD q (oral, rats) of 4520 mg/kg and is classified as nonirritant (skin irritation, rabbits). Diethyl malonate has an LD q (oral, rats) greater than 5000 mg/kg and is also classified as nonirritant (skin irritation, rabbits). Transport classification for both esters is RID/ADR 3, IMDH-Code, lATA-ICAO not restricted. 

Health and Safety Factors. Handling of cyanoacetic acid and cyanoacetates do not present any specific danger or health hazard if handled with the usual precautions. Cyanoacetic acid is classified as a moderate irritant (skin irritation, rabbits) and has an LD q (oral, rats) of 1500 mg/kg. Methyl and ethyl cyanoacetate are both classified as slight irritants (skin irritation, rabbits) and have an LD q (oral, rats) of 3062 and 2820 mg/kg, respectively. Transport classification cyanoacetic acid RID/ADR 8 IMDG-Code 8 lATA/ICAO 6.1. Methyl and ethyl cyanoacetate RID/ADR 6.1 IMDG-Code 6.1 lATA/ICAO 6.1. 

Health and Safety Factors. Isophthahc acid has a low order of toxicity. Inhalation by rats for 4 h at 11.4 g/m showed no toxicity. The LD -level for rats is high at 10.4 g/kg (96). As with terephthahc acid, isophthahc acid was found to form urinary tract calcuh in rats in 90 d when it constituted 3% of their diet. This led to some cancer owing to the presence of the calcuh. Some mild eye irritation is possible, so eye protection should be worn. Otherwise, normal precautions used in handling industrial chemicals should be observed with isophthahc acid. 

Health and Safety Factors. Ttimesic acid is an irritant to the skin, eyes, and respiratory system (140). It is mildly toxic when iagested. The oral LD q ia tats has been reported as 8.4 g/kg (141). Ttimesic acid is flammable, and precautions similar to those noted for tetephthaUc acid and isophthahc acid as regards dust clouds and fire extinguishing agents should be followed. 

Health and Safety Factors. Both pyromellitic acid and its dianhydride irritate skin, eyes, and mucous membranes, and they cause skin sensitization (156). When it comes in contact with moist tissue the dianhydride converts to the acid. Direct contact with should be avoided and protective clothing should be worn in areas where it is used. The LD q for intergastric administration in rats is 2.2—2.6 g/kg (157). In 6-mo experiments, the maximum nontoxic dose was 0.07 mg/kg/d, and it affected the fiver, kidney, and reproductive tract. Precautions against fire and dust explosions as explained in the terephthafic acid section should be foUowed. 

Most aHyl compounds are toxic and many are irritants. Those with a low boiling point are lachrymators. Precautions should be taken at aH times to ensure safe handling (59). AHyl compounds are harmful and may be fatal if inhaled, swaHowed, or absorbed through skin. They are destmctive to the tissues of the mucous membranes and upper respiratory tract, eyes, and skin (Table 4). 

Activated alumina is a relatively innocuous material from a health and safety standpoint. It is nonflammable and nontoxic. Fine dusts can cause eye irritation and there is some record of lung damage because of inhalation of activated alumina dust mixed with siUca [7631-86-9] and iron oxide [1317-61 -9] (30). Normal precautions associated with handling of nuisance dusts should be taken. Activated alumina is normally shipped in moisture-proof containers (bags, dmms, sling bins) because of its strong desiccating action. 

Thorium is potentially hazardous. Einely divided thorium metal and hydrides can be explosive or inflammatory hazards with respect to oxygen and halogens. Einely divided Th02 and other inorganic salts also present an inhalation and irritation hazard. The use of standard precautions, skin covering, and a conventional dust respirator should be sufficient for handling thorium materials. 

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