Porcine pituitary hormone

Porcine pituitary hormone The single Trp-residue is modified, with complete loss of activity 19)... 

Pontocaine amethocaine. porcine pituitary growth hormone (pig somatotropin) is a naturally occurring porcine variant of the PITUITARY HORMONE somatotropin. It is a peptide consisting of 190 amino acid residues. There are a number of naturally occurring molecular variants, synthetic variants or... 

The hypotlialamic peptides, in contrast to some pituitary tropic hormones such as the gonadotropins, are not entirely species specific. Porcine Gn-RH and TRH have been shown to have an effect in humans. The availability of highly purified and synthetic releasing hormones has important diagnostic and therapeutic implications. CRH, GH-RH, Gn-RH, and TRH have all been used to test for pituitary hormone... 

Llpotroplc Hormone. LPH - The involvement of pituitary hormones in releasing free fatty acids from adipose tissue (lipolysis) has been discussed at a symposiuml39. The amino acid sequence (58 amino acids) of porcine a-lipotropic hormone (or-LPH) is closely homologous to that previously reported for ovine y-LPH. The porcine y-LPH sequence appears to be identical to the N-terminal 1-58 sequence of porcine p-LPH in a relationship similar to that previously observed for p- and a-LPH of bovine origin. Also, as has been the case with the ovine hormone, the C-terminal sequence of porcine y-LPH is identical to the entire 18 amino acid sequence of p-MSH from the same species. Partial characterization of human lipotropins was described. ... 

For protein hormones where there was less sequence homology with the equivalent bovine or porcine protein, supplies for clinical use were derived directly from human tissues. Somatotropin or growth hormone (GH) was purihed from cadaver pituitaries. The limitations on GH use were due to its scarcity, which is well described in a review by Frasier [1]. Other peptide hormones purihed from human sources... 

GRF has been isolated and characterized from a human tumor of the pancreas (61) as well as from rat (62), porcine (63), bovine (64), caprine (65), ovine (65), and human (65) hypothalamus stalk-median eminence. It is a 40-44-amino-acid peptide hormone produced in the arcuate nucleus of the hypothalamus and released from neurosecretory nerve terminals of these arcuate neurons, and it is carried by the hypothalamo-hypophysial portal circulation to the anterior pituitary gland where it stimulates growth hormone (GH) secretion (66). 

In the course of the isolation of oxytocin, the second principal hormone of the pituitary gland, vasopressin, a peptide with pressor and antidiuretic effects, was similarly secured in pure form. Porcine glands yielded a vasopressin that contained lysine, while an arginine containing peptide was obtained from the neurohypophysis of cattle. Structure elucidation [63,64] revealed that the two vasopressins are quite analogous to oxytocin, except that isoleucin in position 3 of oxytocin is replaced by phenylalanine and position 8 is occupied by one of the basic amino acids, lysine or arginine, rather than by leucine ... 

Thyroid-stimulating hormone (TSH), a glycoprotein of molecular weight about 25,000 has been purified from bovine, porcine, and human pituitaries The human and bovine hormones have a common C-termlnal pentapeptide sequence, His-Tyr-Lys-Ser-iyr, while the porcine hormoae lacks the C-termlned tyrosine. 

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